Identification of a cyclodextrin inclusion complex of antimicrobial peptide CM4 and its antimicrobial activity

被引：25
|
作者：
Li, Jian-Feng [1 ,2 ]
Zhang, Jia-Xin [3 ]
Wang, Zhi-Guo [1 ]
Yao, Ying-Jia [4 ]
Han, Xu [5 ]
Zhao, You-Long [2 ]
Liu, Jun-Ping [1 ]
Zhang, Shuang-Quan [2 ]
机构：
[1] Hangzhou Normal Univ, Sch Med, Inst Aging Res, Hangzhou 311121, Zhejiang, Peoples R China
[2] Nanjing Normal Univ, Jiangsu Prov Key Lab Mol & Med Biotechnol, Life Sci Coll, Nanjing 210046, Jiangsu, Peoples R China
[3] Nanjing Forestry Univ, Minist Educ, Key Lab Forest Genet & Biotechnol, Coinnovat Ctr Sustainable Forestry Southern China, Nanjing 210037, Jiangsu, Peoples R China
[4] Lishui Univ, Sino Forsign Cooperat, Nursing, Lishui 323499, Zhejiang, Peoples R China
[5] Guangdong Univ Educ, Guangzhou 510303, Guangdong, Peoples R China
来源：
FOOD CHEMISTRY | 2017年 / 221卷
基金：
中国国家自然科学基金;
关键词：
ABP-CM4; beta-Cyclodextrin; Inclusion complex; Antibacterial assay; Stability; CATIONIC ANTIBACTERIAL PEPTIDE; CELL-MEMBRANE; ABP-CM4; MECHANISM; PROTEINS;
D O I：
10.1016/j.foodchem.2016.10.040
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Antibacterial peptide CM4 (ABP-CM4) is a natural product isolated from the silkworm Bombyx mori. It is a small cationic peptide with broad-spectrum activities against harmful microorganisms and may be used as a novel food preservative. However, ABP-CM4 lacks tertiary structure in water-like solutions, which makes it more susceptible to proteases and labile when exposed to air. In this study, beta-cyclodextrin (beta-CD) was chosen to form an inclusion complex with ABP-CM4, which enhanced the physical and chemical properties of ABP-CM4 but did not decrease its antibacterial activity. The storage stability and susceptibility to proteinases of ABP-CM4 were apparently improved under the protection of beta-CD. This technology could also be widely applied to other AMPs as an antimicrobial system to be used in the food industry. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：296 / 301
页数：6
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