A Whole-Grain-Rich Diet Reduces Urinary Excretion of Markers of Protein Catabolism and Gut Microbiota Metabolism in Healthy Men after One Week

被引:37
作者
Ross, Alastair B. [1 ]
Pere-Trepat, Emma [1 ]
Montoliu, Ivan [1 ]
Martin, Francois-Pierre J. [1 ]
Collino, Sebastiano [1 ]
Moco, Sofia [1 ]
Godin, Jean-Philippe [1 ]
Cleroux, Marilyn [1 ]
Guy, Philippe A. [1 ]
Breton, Isabelle [1 ]
Bibiloni, Rodrigo [1 ]
Thorimbert, Anita [1 ]
Tavazzi, Isabelle [1 ]
Tornier, Lionel [1 ]
Bebuis, Aude [1 ]
Bruce, Stephen J. [1 ]
Beaumont, Maurice [1 ]
Fay, Laurent-Bernard [1 ]
Kochhar, Sunil [1 ]
机构
[1] Nestle Res Ctr, CH-1000 Lausanne, Switzerland
关键词
MILDLY HYPERCHOLESTEROLEMIC MEN; CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE; BROWN RICE; WHEAT; CEREAL; FOODS; RISK; OVERWEIGHT; FIBER;
D O I
10.3945/jn.112.172197
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Epidemiological studies consistently find that diets rich in whole-grain (WG) cereals lead to decreased risk of disease compared with refined grain (RG)-based diets. Aside from a greater amount of fiber and micronutrients, possible mechanisms for why WGs may be beneficial for health remain speculative. In an exploratory, randomized, researcher-blinded, crossover trial, we measured metabolic profile differences between healthy participants eating a diet based on WGs compared with a diet based on RGs. Seventeen healthy adult participants (11 female, 6 male) consumed a controlled diet based on either WG-rich or RG-rich foods for 2 wk, followed by the other diet after a 5-wk washout period. Both diets were the same except for the use of WG (150 g/d) or FIG foods. The metabolic profiles of plasma, urine, and fecal water were measured using H-1-nuclear magnetic resonance spectroscopy and gas chromatography-mass spectrometry (plasma only). After 1 wk of intervention, the WG diet led to decreases in urinary excretion of metabolites related to protein catabolism (urea, methylguanadine), lipid (carnitine and acylcarnitines) and gut microbial (4-hydroxyphenylacetate, trimethylacetate, dimethylacetate) metabolism in men compared with the same time point during the FIG intervention. There were no differences between the interventions after 2 wk. Urinary urea, carnitine, and acylcarnitine were lower at wk 1 of the WG intervention relative to the FIG intervention in all participants. Fecal water short-chain fatty acids acetate and butyrate were relatively greater after the WG diet compared to the RG diet. Although based on a small population and for a short time period, these observations suggest that a WG diet may affect protein metabolism.
引用
收藏
页码:766 / 773
页数:8
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