Placental growth factor in suspected preterm pre-eclampsia: a review of the evidence and practicalities of implementation

被引：25

作者：

Hurrell, A. ^{[1
]}

Beardmore-Gray, A. ^{[1
]}

Duhig, K. ^{[1
]}

Webster, L. ^{[1
]}

Chappell, L. C. ^{[1
]}

Shennan, A. H. ^{[1
]}

机构：

[1] Kings Coll London, Sch Life Course Sci, Dept Women & Childrens Hlth, Westminster Bridge Rd, London SE1 7EH, England

来源：

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 2020年 / 127卷 / 13期

关键词：

Angiogenic biomarkers; placental growth factor; pre-eclampsia; soluble fms-like tyrosine kinase 1; CIRCULATING ANGIOGENIC FACTORS; GESTATIONAL-AGE INFANT; DIAGNOSTIC-ACCURACY; SFLT-1/PLGF RATIO; TWIN PREGNANCIES; ADVERSE OUTCOMES; WOMEN; RISK; ULTRASOUND; PLGF;

D O I：

10.1111/1471-0528.16425

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Despite extensive research, the pathophysiology and prevention of pre-eclampsia remain elusive, diagnosis is challenging, and pre-eclampsia remains associated with adverse maternal and perinatal outcomes. Angiogenic biomarkers, including placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1), have been identified as valuable biomarkers for preterm pre-eclampsia, accelerating diagnosis and reducing maternal adverse outcomes by risk stratification, with enhanced surveillance for high-risk women. PlGF-based testing is increasingly being implemented in clinical practice in several countries. This review provides healthcare providers with an understanding of the evidence for PlGF-based testing and describes the practicalities and challenges to implementation.

引用

页码：1590 / 1597

页数：8

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