Design of Selective G-quadruplex Ligands as Potential Anticancer Agents

被引：65
|
作者：
Tan, Jia-Heng [1 ]
Gu, Lian-Quan [1 ]
Wu, Jian-Yong [2 ,3 ]
机构：
[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510080, Guangdong, Peoples R China
[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
[3] Hong Kong Polytech Univ, State Key Lab Chinese Med & Mol Pharmacol, Kowloon, Hong Kong, Peoples R China
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2008年 / 8卷 / 11期
基金：
中国国家自然科学基金;
关键词：
G-quadruplex; G-quartet; ligands; substituted derivatives; affinity and selectivity; DNA interactions; telomerase inhibition;
D O I：
10.2174/138955708785909880
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
G-quadruplex structures are promising targets for design of cancer drugs with high selectivity and low toxicity. This review provides an update of the progress made over the last few years in the design of selective G-quadruplex ligands, and a comprehensive summary of the major design strategies and structural characteristics.
引用
收藏
页码：1163 / 1178
页数：16
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