Growth inhibition of metronidazole-susceptible and metronidazole-resistant strains of Gardnerella vaginalis by lactobacilli in vitro

被引：42
作者：
McLean, NW [1 ]
McGroarty, JA [1 ]
机构：
[1] GLASGOW CALEDONIAN UNIV, DEPT SCI BIOL, GLASGOW G4 0BA, LANARK, SCOTLAND
来源：
APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 1996年 / 62卷 / 03期
关键词：
D O I：
10.1128/AEM.62.3.1089-1092.1996
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Metronidazole resistance was produced in susceptible Gardnerella vaginalis after subculture in the presence of metronidazole. Metronidazole-resistant gardnerellae were less susceptible to growth inhibition by Lactobacillus culture filtrates. A low pH (+/-4) and lactic acid accounted for 60 to 95% of inhibitory activity, and H2O2 accounted for only 0 to 30%. However, in the presence of myeloperoxidase, H2O2-producing lactobacilli decreased the viability of metronidazole-susceptible gardnerellae 2,000-fold.
引用
收藏
页码：1089 / 1092
页数：4
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