Synthesis, structure and cytotoxic activity of platinum(II) dimers with bridging imidate ligands in head-to-head arrangement

被引：11

作者：

Dohta, Y

Kodaka, M

Okada, T

Okamoto, K

Okuno, H

机构：

[1] NATL INST BIOSCI & HUMAN TECHNOL,BIOMOL DEPT,TSUKUBA,IBARAKI 305,JAPAN

[2] UNIV TSUKUBA,DEPT CHEM,TSUKUBA,IBARAKI 305,JAPAN

来源：

INORGANICA CHIMICA ACTA | 1996年 / 252卷 / 1-2期

关键词：

crystal structures; cytotoxic activity; platinum complexes; imidate complexes; dimeric complexes;

D O I：

10.1016/S0020-1693(96)05457-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The cis-diammineplatinum(II) head-to-head dimer complexes with imidate ligands, [Pt-2(NH3)(4)(SI)(2)](NO3)(2) . H2O, [Pt-2(NH3)(4)(EMGI)(2)](NO3)(2) and [Pt-2(NH3)(4)(DMGI)(2)](NO3)(2) (where SI = succinimidate, EMGI = 3-ethyl-3-methylglutarimidate and DMGI = 3,3-dimethylglutarimidate), are prepared from aqueous solutions of platinum(II) in the presence of the corresponding imides. These complexes form a pair of dimers within the crystals stabilized by hydrogen bonds as shown by X-ray structural analysis. They exhibit high antitumor activities against S180 and L1210 cancer cell lines.

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页码：5 / 7

页数：3

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