Myeloperoxidase exerts microbicidal activity against Mycobacterium tuberculosis

被引：33

作者：

Borelli, V

Banfi, E

Perrotta, MG

Zabucchi, G

机构：

[1] Univ Trieste, Dipartimento Fisiol & Patol, I-34127 Trieste, Italy

[2] Univ Trieste, Dipartimento Sci Biomed, I-34127 Trieste, Italy

来源：

INFECTION AND IMMUNITY | 1999年 / 67卷 / 08期

关键词：

D O I：

10.1128/IAI.67.8.4149-4152.1999

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated the antimycobacterial role of myeloperoxidase (MPO), one of the most abundant granule proteins in human neutrophils. Our data indicate that purified MPO, in the presence of hydrogen peroxide, exerts a consistent killing activity against Mycobacterium tuberculosis H37Rv and against a clinical isolate. The activity is time and dose dependent and requires the presence of chloride ions in the assay medium.

引用

页码：4149 / 4152

页数：4

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