Targeting endoplasmic reticulum signaling pathways in cancer

被引：77

作者：

Martinon, Fabio ^{[1
]}

机构：

[1] Univ Lausanne, Dept Biochem, CH-1066 Epalinges, Switzerland

来源：

ACTA ONCOLOGICA | 2012年 / 51卷 / 07期

基金：

瑞士国家科学基金会; 欧洲研究理事会;

关键词：

UNFOLDED PROTEIN RESPONSE; TRANSCRIPTION FACTOR; TUMOR-CELLS; ANTIRETROVIRAL THERAPY; INHIBITOR RITONAVIR; GROWTH ARREST; CALRETICULIN EXPOSURE; IMMUNE-RESPONSES; STRESS-RESPONSE; IN-VITRO;

D O I：

10.3109/0284186X.2012.689113

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The endoplasmic reticulum (ER) orchestrates the production of membrane-bound and secreted proteins. However, its capacity to process the synthesis and folding of protein is limited. Protein overload and the accumulation of misfolded proteins in the ER trigger an adaptive response known as the ER-stress response that is mediated by specific ER-anchored signaling pathways. This response regulates cell functions aimed at restoring cellular homeostasis or at promoting apoptosis of irreparably damaged cells. Activation or deregulation of ER-signaling pathways has been associated with various diseases including cancer. Here we discuss how tumors engage ER-signaling pathways to promote tumorigenesis and how manipulation of this process by anticancer drugs may contribute to cancer treatment.

引用

页码：822 / 830

页数：9

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