Impact of resilience, social support, and personality traits in patients with neuroinflammatory diseases during the COVID-19 pandemic

被引：6

作者：

Jakimovski, Dejan ^{[1
,2
,3
]}

Kavak, Katelyn S. ^{[2
,3
]}

Longbrake, Erin E. ^{[4
]}

Levit, Elle ^{[4
]}

Perrone, Christopher M. ^{[5
,6
]}

Bar-Or, Amit ^{[5
,6
]}

Benedict, Ralph H. B. ^{[2
,3
]}

Riley, Claire S. ^{[7
]}

De Jager, Philip L. ^{[7
]}

Venkatesh, Shruthi ^{[8
]}

Walker, Elizabeth L. S. ^{[8
]}

Xia, Zongqi ^{[8
]}

Weinstock-Guttman, Bianca ^{[2
,3
]}

机构：

[1] Univ Buffalo State Univ New York, Buffalo Neuroimaging Anal Ctr, Dept Neurol, Buffalo, NY USA

[2] Univ Buffalo State Univ New York, Jacobs Sch Med, Dept Neurol, 1010 Main St, Buffalo, NY 14202 USA

[3] Univ Buffalo State Univ New York, Biomed Sci Ctr, 1010 Main St, Buffalo, NY 14202 USA

[4] Yale Univ, Dept Neurol, New Haven, CT USA

[5] Univ Penn, Ctr Neuroinflammat & Expt Therapeut, Philadelphia, PA 19104 USA

[6] Univ Penn, Div MS & Related Disorders, Philadelphia, PA 19104 USA

[7] Columbia Multiple Sclerosis Ctr, Ctr Translat & Computat Neuroirumunol, Dept Neurol, New York, NY USA

[8] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA

来源：

MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2022年 / 68卷

基金：

美国国家卫生研究院;

关键词：

Personality; Loneliness; Resilience; Neuroticism; Patient-reported outcomes; MULTIPLE; LONELINESS; ASSOCIATION; VALIDITY; PEOPLE; SCALE;

D O I：

10.1016/j.msard.2022.104235

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Objective: The COVID-19 pandemic negatively impacted the well-being of persons with neuro-inflammatory diseases (pwNID). Identifying factors that influence the response to challenging conditions could guide supportive care.Methods: 2185 pwNID and 1079 healthy controls (HCs) from five US centers completed an online survey regarding the effects of the COVID-19 pandemic on physical and psychological well-being. Survey instruments included resilience (Connor-Davidson Resilience Scale, CD-RISC), loneliness (UCLA Loneliness Scale), social support (modified social support survey, MSSS-5), personality traits (NEO-Five Factor Inventory, NEO-FFI), and disability (Patient-Determined Disability Steps (PDDS). Step-wise regression models and mediation analyses assessed whether the level of self-reported resilience, size of the social support, and specific personality traits (study predictors) were associated with self-reported disability and/or loneliness (study outcomes).Results: The response rate varied significantly between the questionnaires. While, all pwNID completed the de-mographic questionnaire, 78.8% completed the loneliness questionnaire and 49.7% completed the NEO-FFI. Based on 787 responses, greater neuroticism (standardized fi = 0.312, p < 0.001), less social support (stan-dardized fi =-0.242, p < 0.001), lower extraversion (standardized fi =-0.083, p=0.017), lower agreeableness (standardized fi =-0.119, p < 0.001), and lower resilience (standardized fi =-0.125, p = 0.002) were associated with the feeling of loneliness. Social support and resilience modestly but significantly mediated the association between personality traits and loneliness. Older age (standardized fi = 0.165, p < 0.001) and lower conscien-tiousness (standardized fi =-0.094, p = 0.007) were associated with worse disability (higher PDDS scores). There were no differences in outcomes between pwNID and HCs.Conclusion: Greater social support potentially attenuates the association between neuroticism and the feeling of loneliness in pwNID during the COVID-19 pandemic. Assessment of personality traits may identify pwNID that are in greater need of social support and guide targeted interventions.

引用

页数：9

共 35 条

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