Recent applications of CBT-Cys click reaction in biological systems

被引：13
作者：
Zhu, Yuechao [1 ,2 ]
Zhang, Xian [1 ,2 ]
You, Qidong [1 ,2 ]
Jiang, Zhengyu [1 ,2 ]
机构：
[1] China Pharmaceut Univ, State Key Lab Nat Med, Jiangsu Key Lab Drug Design & Optimizat, Nanjing 210009, Peoples R China
[2] China Pharmaceut Univ, Sch Pharm, Dept Med Chem, Nanjing 210009, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2022年 / 68卷
基金：
中国国家自然科学基金;
关键词：
Click Chemistry; Biorthogonal reaction; CBT-Cys reaction; Firefly luciferin; Biocompatible probe; Nanoparticles; GADOLINIUM NANOPARTICLES; CONDENSATION REACTION; BIOLUMINESCENCE; LUCIFERIN; STRATEGY; BIOCONJUGATION; CYCLOADDITION; LIGATION; EMISSION; DESIGN;
D O I：
10.1016/j.bmc.2022.116881
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Click chemistry is a hot topic in many research fields. A biocompatible reaction from fireflies has attracted increasing attention since 2009. Herein, we focus on the firefly-sourced click reaction between cysteine (Cys) and 2-cyanobenzothiazole (2-CBT). This reaction has many excellent properties, such as rapidity, simplicity and high selectivity, which make it successfully applied in protein labeling, molecular imaging, drug discovery and other fields. Meanwhile, its unique ability to form nanoparticles expands its applications in biological systems. We review its principle, development, and latest applications in the past 5 years and hope this review provides more profound and comprehensive insights to its further application.
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页数：13
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