Use of serum levels of high sensitivity troponin T, galectin-3 and C-terminal propeptide of type I procollagen at long term follow-up in heart failure patients with reduced ejection fraction: Comparison with soluble AXL and BNP

被引:15
作者
Batlle, M. [1 ,2 ]
Campos, B. [3 ]
Farrero, M. [4 ,5 ]
Cardona, M. [4 ,5 ]
Gonzalez, B. [6 ]
Castel, M. A. [4 ,5 ]
Ortiz, J. [4 ,5 ]
Roig, E. [7 ]
Pulgarin, M. J. [1 ,2 ]
Ramirez, J. [8 ]
Bedini, J. L. [6 ]
Sabate, M. [1 ,2 ]
de Frutos, P. Garcia [9 ,10 ]
Perez-Villa, F. [4 ,5 ]
机构
[1] Hosp Clin Barcelona, Inst Biomed Res August Pi & Sunyer IDIBAPS, Barcelona, Spain
[2] Hosp Clin Barcelona, Cardiovasc Clin Inst, Barcelona, Spain
[3] Univ Barcelona, Dept Publ Hlth, E-08007 Barcelona, Spain
[4] Hosp Clin Barcelona, Cardiovasc Clin Inst, Heart Failure & Transplant Unit, Barcelona, Spain
[5] Inst Biomed Res August Pi & Sunyer IDIBAPS, Barcelona, Spain
[6] Hosp Clin Barcelona, Core Lab, Barcelona, Spain
[7] Univ Autonoma Barcelona, Inst Recerca Biomed IIB St Pau, Hosp Santa Creu & St Pau, Heart Failure Unit,Cardiol Dept, E-08193 Barcelona, Spain
[8] Hosp Clin Barcelona, Dept Pathol Anat, Barcelona, Spain
[9] Inst Invest Biomed Barcelona IIBB CSIC, Dept Cell Death & Proliferat, Barcelona, Spain
[10] IDIBAPS, Barcelona, Spain
关键词
Heart failure; AXL receptor tyrosine kinase; High sensitivity troponin T; Galectin-3; C-terminal propeptide of type I procollagen; Prognosis; Myocardial damage; BRAIN NATRIURETIC PEPTIDE; CARDIAC TROPONIN; RISK STRATIFICATION; DILATED CARDIOMYOPATHY; MYOCARDIAL FIBROSIS; AMBULATORY PATIENTS; BIOMARKERS; DYSFUNCTION; GUIDELINES; MORTALITY;
D O I
10.1016/j.ijcard.2016.09.079
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Prognostic biomarkers are needed to improve the management of the heart failure (HF) epidemic, being the brain natriuretic peptides the most valuable. Here we evaluate 3 biomarkers, high sensitivity troponin T (hs-TnT), galectin-3 (Gal-3) and C-terminal propeptide of type I procollagen (CICP), compare them with a recently described new candidate (sAXL), and analyze their relationship with BNP. Methods: HF patients with reduced ejection fraction (n=192) were included in this prospective observational study, with measurements of candidate biomarkers, functional, clinical and echocardiographic variables. A Cox regression model was used to determine predictors for clinical events, i.e. all-cause mortality and heart transplantation. Results: Hs-TnT circulating values were correlated to clinical characteristics indicative of more advanced HF. When analyzing the event-free survival at a mean follow-up of 3.6 years, patients in the higher quartile of either BNP, hs-TnT, CICP and sAXL had increased risk of suffering a clinical event, but not Gal-3. Combination of high sAXL and BNP values had greater predictive value (HR 6.8) than high BNP alone (HR 4.9). In a multivariate Cox regression analysis, BNP, sAXL and NYHA class were independent risk factors for clinical events. Conclusions: In this HF cohort, hs-TnT is a good HF marker and has a very significant prognostic value. The prognostic value of CICP and sAXL was of less significance. However, hs-TnT did not add predictive value to BNP, while sAXL did. This suggests that elevated troponin has a common origin with BNP, while sAXL could represent an independent pathological mechanism. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:113 / 119
页数:7
相关论文
共 41 条
[41]   Multimarker strategy for the prediction of 31 days cardiac death in patients with acutely decompensated chronic heart failure [J].
Zairis, Michael N. ;
Tsiaousis, George Z. ;
Georgilas, Anastassios Theodossis ;
Makrygiannis, Stamatis S. ;
Adamopoulou, Evdokia N. ;
Handanis, Stelios M. ;
Batika, Pelagia C. ;
Prekates, Athanasios A. ;
Velissaris, Dimitris ;
Kouris, Nikolaos T. ;
Mytas, Demetrios Z. ;
Babalis, Demetrios K. ;
Karidis, Kostas S. ;
Foussas, Stefanos G. .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2010, 141 (03) :284-290