A fluorescent and colorimetric probe enables simultaneous differential detection of Hg2+ and Cu2+ by two different mechanisms

被引：100
作者：
Gao, Yunling [1 ]
Zhang, Cong [1 ]
Peng, Shuwen [2 ]
Chen, Haiyan [2 ]
机构：
[1] Zhejiang Univ Technol, Coll Chem Engn, State Key Lab Breeding Base Green Chem Synth Tech, Hangzhou 310032, Zhejiang, Peoples R China
[2] China Pharmaceut Univ, Sch Engn, Dept Biomed Engn, Nanjing 210009, Jiangsu, Peoples R China
来源：
SENSORS AND ACTUATORS B-CHEMICAL | 2017年 / 238卷
基金：
中国国家自然科学基金;
关键词：
Probe; Copper; Mercury; Fluorescence; Colorimetric; Simultaneous differential detection; TRANSITION-METAL IONS; DUAL CHEMOSENSOR; SCHIFF-BASE; COPPER; RECOGNITION; MERCURY; HG(II); CONJUGATE; DISEASES; RECEPTOR;
D O I：
10.1016/j.snb.2016.07.076
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A new Schiff-base fluorescence probe CS containing benzimidazole and coumarin fluorophores was synthesized and characterized by NMR, IR and ESI-MS. Fluorescence and absorption spectra show the unique changes in the presence of Hg2+ and Cu2+. Hg2+ induces a remarkable fluorescence enhancement and results in mercury-promoted hydrolysis of a mercury-CS complex to convert the imine group to the aldehyde group. Cu2+ leads to a colorimetric change from colorless to pale yellow and causes formation of a copper-CS complex. Thus, CS can act as a fluorescent chemodosimeter for Hg2+ and a naked-eye chemosensor Cu2+. The cell imaging experiments for Hg2+ show a slow enhancement of a bright blue fluorescence with increasing incubation time, while Cu2+ instantly quenches the fluorescence and then the fluorescence intensity has no further change by extending the incubation time. Therefore, the probe CS shows its potential application for simultaneous differential detection of Hg2+ and Cu2+ in living cells based on the fluorescence response time. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：455 / 461
页数：7
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