NEW DATA ON ISOPENICILLIN N SYNTHASE AND PEROXISOME COLOCATION IN THE HYPHAL CELLS OF PENICILLIUM CHRYSOGENUM PQ-96-PEXOPHAGY AND EXOCYTOSIS

被引：0
作者：
Kurzatkowski, Wieslaw [1 ]
Gorska, Paulina [1 ]
Glowka, Malgorzata [1 ]
Woznica, Katarzyna [1 ]
Zasada, Aleksandra [1 ]
机构：
[1] Natl Inst Hyg, Natl Inst Publ Hlth, Dept Epidemiol, PL-00791 Warsaw, Poland
来源：
ADVANCEMENTS OF MICROBIOLOGY | 2019年 / 58卷 / 01期
关键词：
Penicillium chrysogenum; penicillin G; biosynthesis; secretion; pexophagy; exocytosis; detoxification; INDUSTRIAL STRAINS; G SECRETION; BIOSYNTHESIS; COMPARTMENTALIZATION; MEMBRANE; ACID;
D O I：
10.21307/PM-2019.58.1.080
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The machinery of antibiotic production by Penicillium chrysogenum PQ-96 is composed of co-located cytosolic and peroxisomal enzymes of the penicillin G biosynthesis pathway. Pexophagy and exocytosis should be currently considered as an alternative for penicillin G secretion from the mycelial cells. Penicillin G overproduction is a cellular detoxification process, protecting the mycelium from the toxicity of the antibiotic precursor.
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页码：80 / 85
页数：6
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