An approach to alicyclic ring-fused xanthines

被引：10
作者：
Liubchak, Kostiantyn [1 ]
Tolmachev, Andrey [2 ,3 ]
Grygorenko, Oleksandr O. [2 ,3 ]
Nazarenko, Kostiantyn [1 ]
机构：
[1] Inst Organ Chem NAS Ukraine, UA-02094 Kiev, Ukraine
[2] Kyiv Natl Taras Shevchenko Univ, UA-01601 Kiev, Ukraine
[3] Enamine Ltd, UA-01103 Kiev, Ukraine
来源：
TETRAHEDRON | 2012年 / 68卷 / 41期
关键词：
Nitrogen heterocycles; Copper-catalyzed arylation; Imidazoles; Xantines; Amidines; CATALYZED COUPLING REACTION; EFFICIENT SYNTHESIS; DERIVATIVES; BENZIMIDAZOLES; CHEMISTRY; POTENT; TRANSFORMATION; 6-AMINOURACIL; BENZOXAZOLES; IMIDAZOLES;
D O I：
10.1016/j.tet.2012.08.014
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient three-step approach to the synthesis of five to eight-membered alicyclic ring-fused xanthines was developed. The method included reaction of lactim or thiolactim ethers with 6-aminouracils, followed by bromination and copper-catalyzed arylation. The procedure allowed preparation of the title compounds in 21-36% overall yields. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8564 / 8571
页数：8
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