Parallel kinetic resolution of active esters using designer oxazolidin-2-ones derived from phenylglycine

被引：12

作者：

Chavda, Sameer ^{[1
]}

Coulbeck, Elliot ^{[1
]}

Dingjan, Marco ^{[1
]}

Eames, Jason ^{[1
]}

Flinn, Anthony ^{[2
]}

Northen, Julian ^{[2
]}

机构：

[1] Univ Hull, Dept Chem, Kingston Upon Hull HU6 7RX, N Humberside, England

[2] Onyx Sci Ltd, Units 97 98, Sunderland SR5 2TQ, England

来源：

TETRAHEDRON-ASYMMETRY | 2008年 / 19卷 / 13期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/j.tetasy.2008.06.020

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The parallel kinetic resolution of racemic pentafluorophenyl 2-phenylpropionate using an equimolar combination of quasi-eriantiomeric oxazolidin-2-ones is discussed. The levels of diastereoselectivity were excellent (>90% de) leading to separable quasi-enantiomeric oxazolidin-2-one adducts in good yield. This methodology was subsequently used to resolve a series of 2-aryl propionic and butanoic acids. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1536 / 1548

页数：13

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