Antibacterial carbazole alkaloids from Clausena harmandiana twigs

被引：55

作者：

Maneerat, Wisanu ^{[1
]}

Phakhodee, Wong ^{[1
]}

Ritthiwigrom, Thunwadee ^{[2
]}

Cheenpracha, Sarot ^{[3
]}

Promgool, Trinop ^{[1
]}

Yossathera, Kulsiri ^{[1
]}

Deachathai, Suwanna ^{[1
]}

Laphookhieo, Surat ^{[1
]}

机构：

[1] Mae Fah Luang Univ, Nat Prod Res Lab, Sch Sci, Muang 57100, Chiang Rai, Thailand

[2] Chiang Mai Univ, Dept Chem, Fac Sci, Chiang Mai 50200, Thailand

[3] Univ Phayao, Sch Sci, Muang 56000, Phayao, Thailand

来源：

FITOTERAPIA | 2012年 / 83卷 / 06期

关键词：

Clausena harmandiana; Carbazole alkaloid; Harmandianamines A-C; Anti-bacteria; Rutaceae; CHEMICAL-CONSTITUENTS; ROOT BARK; COUMARINS;

D O I：

10.1016/j.fitote.2012.04.026

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new carbazole alkaloids, harmandianamines A-C (1-3), together with fifteen known compounds (4-18) were isolated from the twigs of Clausena harmandiana. The structures were elucidated by spectroscopic methods, including UV, IR, NMR, and MS. The antibacterial activity against Escherichia coli TISTR 780, Salmonella typhimurium TISTR 292, Staphylococcus aureus TISTR 1466 and methicillin-resistant S. aureus (MRSA) SK1 of some isolated compounds was also evaluated. Compound 6 exhibited significant antibacterial activity against MRSA SK1 with an MIC value of 0.25 mu g/mL which higher than that of standard drug, vancomycin (MIC value = 1 mu g/mL) whereas compounds 14 and 5 showed strong activity with MIC values of 4 and 8 mu g/mL, respectively. Only compound 14 showed strong antibacterial activity against S. aureus TISTR 1466 with an MIC value of 4 mu g/mL (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：1110 / 1114

页数：5

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