Estrogenic influences in pain processing

被引：101

作者：

Amandusson, Asa ^{[1
]}

Blomqvist, Anders ^{[2
]}

机构：

[1] Uppsala Univ, Dept Clin Neurophysiol, S-75185 Uppsala, Sweden

[2] Linkoping Univ, Fac Hlth Sci, Dept Clin & Expt Med, Div Cell Biol, S-58185 Linkoping, Sweden

来源：

FRONTIERS IN NEUROENDOCRINOLOGY | 2013年 / 34卷 / 04期

基金：

瑞典研究理事会;

关键词：

Nociception; Gonadal hormones; Estrogens; Estrogen receptors; Spinal dorsal horn; Medullary dorsal horn; Steroid hormones; Enkephalin; Opioid; Pain mechanisms; RAT SPINAL-CORD; CENTRAL-NERVOUS-SYSTEM; DORSAL-ROOT GANGLION; PREPROENKEPHALIN MESSENGER-RNA; RECEPTOR-IMMUNOREACTIVE NEURONS; HORMONE REPLACEMENT THERAPY; METABOTROPIC GLUTAMATE RECEPTORS; ESTRADIOL-CONCENTRATING CELLS; INDUCED NOCICEPTIVE RESPONSES; MIDBRAIN PERIAQUEDUCTAL GRAY;

D O I：

10.1016/j.yfrne.2013.06.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Gonadal hormones not only play a pivotal role in reproductive behavior and sexual differentiation, they also contribute to thermoregulation, feeding, memory, neuronal survival, and the perception of somatosensory stimuli. Numerous studies on both animals and human subjects have also demonstrated the potential effects of gonadal hormones, such as estrogens, on pain transmission. These effects most likely involve multiple neuroanatomical circuits as well as diverse neurochemical systems and they therefore need to be evaluated specifically to determine the localization and intrinsic characteristics of the neurons engaged. The aim of this review is to summarize the morphological as well as biochemical evidence in support for gonadal hormone modulation of nociceptive processing, with particular focus on estrogens and spinal cord mechanisms. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：329 / 349

页数：21

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