(n-3) Fatty Acid Content of Red Blood Cells Does Not Predict Risk of Future Cardiovascular Events following an Acute Coronary Syndrome

被引:35
作者
Aarsetoey, Hildegunn [1 ,3 ]
Ponitz, Volker [2 ,3 ]
Grundt, Heidi [1 ,3 ]
Staines, Harry [4 ]
Harris, William S. [5 ]
Nilsen, Dennis W. T. [2 ,3 ]
机构
[1] Stavanger Univ Hosp, Dept Med, N-4068 Stavanger, Norway
[2] Stavanger Univ Hosp, Div Cardiol, N-4068 Stavanger, Norway
[3] Univ Bergen, Inst Med, N-5020 Bergen, Norway
[4] Sigma Stat Serv, Balmullo KY16 ODH, Scotland
[5] Univ S Dakota, Sanford Sch Med, Sioux Falls, SD 57069 USA
关键词
SUDDEN CARDIAC DEATH; FISH-OIL; EICOSAPENTAENOIC ACID; MYOCARDIAL-INFARCTION; DIETARY ADVICE; OMEGA-3; INDEX; OMEGA-3-FATTY-ACIDS; DISEASE; HEART; PREVENTION;
D O I
10.3945/jn.108.096446
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
A reduced risk of fatal coronary artery disease has been associated with a high intake of (n-3) fatty acids (FA) and a direct cardioprotective effect by their incorporation into myocardial cells has been suggested. Based on these observations, the omega-3 index (eicosapentaenoic acid 4 docosahexaenoic acid in cell membranes of RBC expressed as percent of total FA) has been suggested as a new risk marker for cardiac death. In this study, our aim was to evaluate the omega-3 index as a prognostic risk marker following hospitalization with an acute coronary syndrome (ACS). The omega-3 index was measured at admission in 460 patients with an ACS as defined by Troponin-T (TnT) >= 0.02 mu g/L. During a 2-y follow-up, recurrent myocardial infarctions (MI) (defined as TnT >0.06 mu g/L with a typical MI presentation) and cardiac and all-cause mortality were registered. Cox regression analyses were used to relate the risk of new events to the quartiles of the omega-3 index at inclusion. After correction for age, sex, previous heart disease, hypertension, diabetes, smoking, high-sensitivity C-reactive protein, brain natriuretic peptide, creatinine, total cholesterol, HDL-cholesterol, triacylglycerol, homocysteine, BMI, and medication, there was no significant reduction in risk for all-cause mortality, cardiac death, or MI with increasing values of the index. In conclusion, we could not confirm the omega-3 index as a useful prognostic risk marker following an ACS. J. Nutr. 139: 507-513, 2009.
引用
收藏
页码:507 / 513
页数:7
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