Lin28: Primal Regulator of Growth and Metabolism in Stem Cells

被引：394

作者：

Shyh-Chang, Ng ^{[1
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Daley, George Q. ^{[1
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机构：

[1] Boston Childrens Hosp, Div Pediat Hematol Oncol, Stem Cell Transplantat Program, Boston, MA 02115 USA

[2] Dana Farber Canc Inst, Boston, MA 02115 USA

[3] Harvard Stem Cell Inst, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[5] Manton Ctr Orphan Dis Res, Boston, MA 02115 USA

[6] Howard Hughes Med Inst, Boston, MA 02115 USA

来源：

CELL STEM CELL | 2013年 / 12卷 / 04期

关键词：

BINDING PROTEIN LIN28; PLURIPOTENCY FACTOR LIN28; TUMOR-INITIATING CELLS; LET-7; MICRORNA; SELF-RENEWAL; NUCLEAR RECEPTOR; POSTTRANSCRIPTIONAL REGULATION; PROMOTES TRANSFORMATION; DEVELOPMENTAL AGE; LIN-28; HOMOLOG;

D O I：

10.1016/j.stem.2013.03.005

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

In recent years, the highly conserved Lin28 RNA-binding proteins have emerged as factors that define stemness in several tissue lineages. Lin28 proteins repress let-7 microRNAs and influence mRNA translation, thereby regulating the self-renewal of mammalian embryonic stem cells. Subsequent discoveries revealed that Lin28a and Lin28b are also important in organismal growth and metabolism, tissue development, somatic reprogramming, and cancer. In this review, we discuss the Lin28 pathway and its regulation, outline its roles in stem cells, tissue development, and pathogenesis, and examine the ramifications for re-engineering mammalian physiology.

引用

页码：395 / 406

页数：12

共 150 条

[1] The let-7 microRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans [J].