Regulating DNA Replication in Eukarya

被引：117

作者：

Siddiqui, Khalid ^{[1
]}

On, Kin Fan ^{[1
]}

Diffley, John F. X. ^{[1
]}

机构：

[1] Imperial Canc Res Fund, Clare Hall Labs, London Res Inst, Canc Res UK, S Mimms EN6 3LD, Herts, England

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2013年 / 5卷 / 09期

关键词：

ORIGIN RECOGNITION COMPLEX; MINICHROMOSOME MAINTENANCE PROTEINS; CYCLIN-DEPENDENT KINASES; ANAPHASE-PROMOTING COMPLEX; HBO1 HISTONE ACETYLASE; LICENSING FACTOR CDT1; S-PHASE; CELL-CYCLE; FISSION YEAST; RE-REPLICATION;

D O I：

10.1101/cshperspect.a012930

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

DNA replication is tightly controlled in eukaryotic cells to ensure that an exact copy of the genetic material is inherited by both daughter cells. Oscillating waves of cyclin-dependent kinase (CDK) and anaphase-promoting complex/cyclosome (APC/C) activities provide a binary switch that permits the replication of each chromosome exactly once per cell cycle. Work from several organisms has revealed a conserved strategy whereby inactive replication complexes are assembled onto DNA during periods of low CDK and high APC activity but are competent to execute genome duplication only when these activities are reversed. Periods of high CDK and low APC/C serve an essential function by blocking reassembly of replication complexes, thereby preventing rereplication. Higher eukaryotes have evolved additional CDK-independent mechanisms for preventing rereplication.

引用

页数：20

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