Regulating DNA Replication in Eukarya

被引：117

作者：

Siddiqui, Khalid ^{[1
]}

On, Kin Fan ^{[1
]}

Diffley, John F. X. ^{[1
]}

机构：

[1] Imperial Canc Res Fund, Clare Hall Labs, London Res Inst, Canc Res UK, S Mimms EN6 3LD, Herts, England

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2013年 / 5卷 / 09期

关键词：

ORIGIN RECOGNITION COMPLEX; MINICHROMOSOME MAINTENANCE PROTEINS; CYCLIN-DEPENDENT KINASES; ANAPHASE-PROMOTING COMPLEX; HBO1 HISTONE ACETYLASE; LICENSING FACTOR CDT1; S-PHASE; CELL-CYCLE; FISSION YEAST; RE-REPLICATION;

D O I：

10.1101/cshperspect.a012930

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

DNA replication is tightly controlled in eukaryotic cells to ensure that an exact copy of the genetic material is inherited by both daughter cells. Oscillating waves of cyclin-dependent kinase (CDK) and anaphase-promoting complex/cyclosome (APC/C) activities provide a binary switch that permits the replication of each chromosome exactly once per cell cycle. Work from several organisms has revealed a conserved strategy whereby inactive replication complexes are assembled onto DNA during periods of low CDK and high APC activity but are competent to execute genome duplication only when these activities are reversed. Periods of high CDK and low APC/C serve an essential function by blocking reassembly of replication complexes, thereby preventing rereplication. Higher eukaryotes have evolved additional CDK-independent mechanisms for preventing rereplication.

引用

页数：20

共 247 条

[1] Chromatin regulates origin activity in Drosophila follicle cells [J].

Aggarwal, BD ;

Calvi, BR .

NATURE, 2004, 430 (6997) :372-376

[2] Cdc6 chromatin affinity is unaffected by serine-54 phosphorylation, S-phase progression, and overexpression of cyclin A [J].

Alexandrow, MG ;

Hamlin, JL .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (04) :1614-1627

[3] SCF-mediated protein degradation and cell cycle control [J].

Ang, XLL ;

Harper, JW .

ONCOGENE, 2005, 24 (17) :2860-2870

[4] The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication [J].

Aparicio, Toms ;

Guillou, Emmanuelle ;

Coloma, Javier ;

Montoya, Guillermo ;

Mendez, Juan .

NUCLEIC ACIDS RESEARCH, 2009, 37 (07) :2087-2095

[5] PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication [J].

Arias, EE ;

Walter, JC .

NATURE CELL BIOLOGY, 2006, 8 (01) :84-U33

[6] Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts [J].

Arias, EE ;

Walter, JC .

GENES & DEVELOPMENT, 2005, 19 (01) :114-126

[7] Role of the Orc6 protein in origin recognition complex-dependent DNA binding and replication in Drosophila melanogaster [J].

Balasov, Maxim ;

Huijbregts, Richard P. H. ;

Chesnokov, Igor .

MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (08) :3143-3153

[8] GEMC1 is a TopBP1-interacting protein required for chromosomal DNA replication [J].

Balestrini, Alessia ;

Cosentino, Claudia ;

Errico, Alessia ;

Garner, Elizabeth ;

Costanzo, Vincenzo .

NATURE CELL BIOLOGY, 2010, 12 (05) :484-U156

[9] Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis [J].

Andrea Ballabeni ;

Marina Melixetian ;

Raffaella Zamponi ;

Laura Masiero ;

Federica Marinoni ;

Kristian Helin .

The EMBO Journal, 2004, 23 (15) :3122-3132

[10] Cdc18 transcription and proteolysis couple S phase to passage through mitosis [J].

Baum, B ;

Nishitani, H ;

Yanow, S ;

Nurse, P .

EMBO JOURNAL, 1998, 17 (19) :5689-5698

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