APOBEC3 cytidine deaminases: Distinct antiviral actions along the retroviral life cycle

被引：31

作者：

Chiu, YL

Green, WC

机构：

[1] Univ Calif San Francisco, Gladstone Inst Virol & Immunol, San Francisco, CA 94141 USA

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA 94141 USA

[3] Univ Calif San Francisco, Dept Microbiol, San Francisco, CA 94141 USA

[4] Univ Calif San Francisco, Dept Immunol, San Francisco, CA 94141 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2006年 / 281卷 / 13期

关键词：

D O I：

10.1074/jbc.R500021200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The field of human immunodeficiency virus ( HIV) biology has been galvanized by the discovery of innate APOBEC3 cytidine deaminases, which pose powerful barriers to the replication of HIV and other retroviruses. Rapid progress has been made in defining their action, intriguing regulation within cells, expanded range of retroviral targets, and counterstrikes utilized by retroviruses against them. Although scientifically fascinating, advances in APOBEC3 biology may lead to new antiviral drugs and improved lentiviral vectors for gene therapy.

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收藏

页码：8309 / 8312

页数：4

相关论文

共 83 条

[71] Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes [J].

Unutmaz, D ;

KewalRamani, VN ;

Marmon, S ;

Littman, DR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (11) :1735-1746

[72] Analysis of HIV-1 viral infectivity factor-mediated proteasome-dependent depletion of APOBEC3G [J].

Wichroski, MJ ;

Ichiyama, K ;

Rana, TM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (09) :8387-8396

[73] A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV-1 and HIV-2 Vif proteins [J].

Wiegand, HL ;

Doehle, BP ;

Bogerd, HP ;

Cullen, BR .

EMBO JOURNAL, 2004, 23 (12) :2451-2458

[74] A single amino acid substitution in human APOBEC3G antiretroviral enzyme confers resistance to HIV-1 virion infectivity factor-induced depletion [J].

Xu, HZ ;

Svarovskaia, ES ;

Barr, R ;

Zhang, YJ ;

Khan, MA ;

Strebel, K ;

Pathak, VK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (15) :5652-5657

[75] APOLIPOPROTEIN-B MESSENGER-RNA-EDITING PROTEIN INDUCES HEPATOCELLULAR-CARCINOMA AND DYSPLASIA IN TRANSGENIC ANIMALS [J].

YAMANAKA, S ;

BALESTRA, ME ;

FERRELL, LD ;

FAN, JL ;

ARNOLD, KS ;

TAYLOR, S ;

TAYLOR, JM ;

INNERARITY, TL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (18) :8483-8487

[76] Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome [J].

Yu, Q ;

König, R ;

Pillai, S ;

Chiles, K ;

Kearney, M ;

Palmer, S ;

Richman, D ;

Coffin, JM ;

Landau, NR .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2004, 11 (05) :435-442

[77] Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex [J].

Yu, XH ;

Yu, YK ;

Liu, BD ;

Luo, K ;

Kong, W ;

Mao, PY ;

Yu, XF .

SCIENCE, 2003, 302 (5647) :1056-1060

[78] Selective assembly of HIV-1 Vif-Cul5-ElonginB-ElonginC E3 ubiquitin ligase complex through a novel SOCS box and upstream cysteines [J].

Yu, YK ;

Xiao, ZX ;

Ehrlich, ES ;

Yu, XH ;

Yu, XF .

GENES & DEVELOPMENT, 2004, 18 (23) :2867-2872

[79] HIV-1 ENTRY INTO QUIESCENT PRIMARY LYMPHOCYTES - MOLECULAR ANALYSIS REVEALS A LABILE, LATENT VIRAL STRUCTURE [J].

ZACK, JA ;

ARRIGO, SJ ;

WEITSMAN, SR ;

GO, AS ;

HAISLIP, A ;

CHEN, ISY .

CELL, 1990, 61 (02) :213-222

[80] APOBEC3G incorporation into human immunodeficiency virus type 1 particles [J].

Zennou, W ;

Perez-Caballero, D ;

Göttlinger, H ;

Bieniasz, PD .

JOURNAL OF VIROLOGY, 2004, 78 (21) :12058-12061

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