Autoimmune hepatitis: Challenges and novelties

被引：12

作者：

Olivas, Ignasi ^{[1
]}

Rodriguez -Tajes, Sergio ^{[1
]}

Londono, Maria Carlota ^{[1
]}

机构：

[1] Hosp Clin Barcelona, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Serv Hepatol, Inst Invest Biomed August Pi Sunyer IDIBAPS i, Barcelona, Spain

来源：

MEDICINA CLINICA | 2022年 / 159卷 / 06期

关键词：

Autoimmune hepatitis; Acute autoimmune hepatitis; Drug-induced liver injury; Antibodies; Treatment; MYCOPHENOLATE-MOFETIL; TACROLIMUS; THERAPY; EFFICACY; CYCLOSPORINE; INTOLERANT; MANAGEMENT; DIFFICULT; 2ND-LINE; CORTICOSTEROIDS;

D O I：

10.1016/j.medcli.2022.04.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autoimmune hepatitis is a chronic inflammatory disease of the liver. The etiology is partly unknown and commonly affects women of all ages. It is characterized by increase in transaminase and immuno-globulin G levels, autoantibodies, and portal inflammatory infiltrate with interface hepatitis in the liver biopsy. The treatment is based on the combination of corticoids and azathioprine, but 20-40% of patients require second-or third-line therapies due to intolerance or insufficient response. Here, we will revise the most important aspects regarding the diagnosis and treatment of autoimmune hepatitis emphasizing the challenges faced in clinical practice.(c) 2022 Elsevier Espana, S.L.U. All rights reserved.

引用

页码：289 / 298

页数：10

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