Copper Hydride-Catalyzed Conjugate Reduction-Aldol Addition Domino Reaction of α,β-Unsaturated Carboxylates with Ketones

被引：10
作者：
Li, Zengchang [1 ]
Jiang, Lan [2 ]
Li, Zhengning [1 ,2 ]
Chen, Huiying [3 ]
机构：
[1] Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Liaoning, Peoples R China
[2] Dalian Univ, Liaoning Key Lab Bioorgan Chem, Dalian 116622, Liaoning, Peoples R China
[3] Dalian Nationalities Univ, Coll Life Sci, Dalian 116600, Liaoning, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2013年 / 31卷 / 04期
关键词：
reduction; aldol addition; domino reaction; copper hydride; catalysis; STRYKERS REAGENT; POLYCYCLIC DERIVATIVES; ASYMMETRIC-SYNTHESIS; CYCLIZATION; COMPLEXES; ESTERS; HYDROSILYLATION; ALDEHYDES; (BDP)CUH; ACCESS;
D O I：
10.1002/cjoc.201300036
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Copper hydride-catalyzed conjugate reduction-intermolecular aldol addition domino reactions were realized using ,-unsaturated carboxylates as hydride acceptors and a silane as the reducing reagent. High diastereoselectivities were achieved with 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene as the ligand and tert-butyl acrylate as the hydride acceptor.
引用
收藏
页码：539 / 544
页数：6
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