Ascorbic acid-Catalyzed One-Pot Three-Component Biginelli Reaction: A Practical and Green Approach towards Synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones

被引：13

作者：

Sehout, Imene ^{[1
]}

Boulcina, Raouf ^{[1
]}

Boumoud, Boudjemaa ^{[1
]}

Berree, Fabienne ^{[2
]}

Carboni, Bertrand ^{[2
]}

Debache, Abdelmadjid ^{[1
]}

机构：

[1] Univ Constantine 1, Fac Sci Exactes, Dept Chim, Lab Synth Mol Interets Biol, Constantine 25000, Algeria

[2] Univ Rennes 1, UMR CNRS 6226, F-35042 Rennes, France

来源：

LETTERS IN ORGANIC CHEMISTRY | 2013年 / 10卷 / 07期

关键词：

Multicomponent reaction; one-pot synthesis; Biginelli reaction; 3; 4dihydropyrimidin-2(1H)-ones/thiones; ascorbic acid; CALCIUM-CHANNEL BLOCKERS; SOLVENT-FREE BIGINELLI; EFFICIENT SYNTHESIS; REUSABLE CATALYST; IMPROVED PROTOCOL; CHLORIDE; DIHYDROPYRIMIDINONES; MILD; 3,4-DIHYDROPYRIMIDIN-2-(1H)-ONES; TRIFLATE;

D O I：

10.2174/15701786113109990014

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via a three-component Biginelli condensation of aldehyde, ethyl acetoacetate, and urea or thiourea in the presence of a catalytic amount of ascorbic acid (5 mol %) is described. The reaction proceeded efficiently under solvent-free conditions at 80 degrees C to afford the desired products in moderate to good yields.

引用

页码：463 / 467

页数：5

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