A macromolecular Gd(III) complex as pH-responsive relaxometric probe for MRI applications

被引：80
|
作者：
Aime, S
Botta, M
Crich, SG
Giovenzana, G
Palmisano, G
Sisti, M
机构：
[1] Univ Turin, Dipartimento Chim IFM, I-10125 Turin, Italy
[2] Univ Piemonte Orientale Amedeo Avogadro, Dipartimento Sci & Tecnol Avanzate, I-15100 Alessandria, Italy
[3] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy
[4] Univ Piemonte Orientale, Dipartimento Sci Med, I-28100 Novara, Italy
[5] Univ Insubria, Dipartimento Sci CC FF MM, I-22100 Como, Italy
来源：
CHEMICAL COMMUNICATIONS | 1999年 / 16期
关键词：
D O I：
10.1039/a900499h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The ability of the paramagnetic macromolecular complex (GdDO3ASQ)(30)-Orn(114) to enhance the water proton relaxation rate has been found to be a function of pH; this behaviour is related to the structural changes occurring in the polypeptide upon protonation of the side-chain NH(2) groups.
引用
收藏
页码：1577 / 1578
页数：2
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