Pathogenicity, host responses and implications for management of enterohemorrhagic Escherichia coli O157:H7 infection

被引：26
|
作者：
Ho, Nathan K. [1 ,2 ]
Henry, Aleah C. [3 ]
Johnson-Henry, Kathene [1 ]
Sherman, Philip M. [1 ,2 ]
机构：
[1] Hosp Sick Children, Dept Paediat, Toronto, ON M5G 1X8, Canada
[2] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
[3] McMaster Univ, Dept Chem Engn, Hamilton, ON L8S 4L7, Canada
来源：
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2013年 / 27卷 / 05期
关键词：
Escherichia coli; Host response; Irritable bowel syndrome; Pathogenicity; Treatment; HEMOLYTIC-UREMIC SYNDROME; SHIGA-TOXIN; INBORN-ERRORS; IFN-GAMMA; DIARRHEA; PATHOGENESIS; PHOSPHORYLATION; CYTOTOXIN; OUTBREAKS; CHILDREN;
D O I：
10.1155/2013/138673
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Enterohemorrhagic Escherichia coli serotype O157:H7 is a food- and waterborne pathogen that causes significant morbidity and mortality in both developing and industrialized nations. The present review focuses on the history, epidemiology and evolution of the pathogen; provides a mechanistic overview of major virulence factors (including Shiga toxins, locus of enterocyte effacement pathogenicity island and pO157 plasmid); discusses host immune responses to infection; considers available animal models; and provides an overview of current and potential future management considerations.
引用
收藏
页码：281 / 285
页数：5
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