Pathogenicity, host responses and implications for management of enterohemorrhagic Escherichia coli O157:H7 infection

被引：26

作者：

Ho, Nathan K. ^{[1
,2
]}

Henry, Aleah C. ^{[3
]}

Johnson-Henry, Kathene ^{[1
]}

Sherman, Philip M. ^{[1
,2
]}

机构：

[1] Hosp Sick Children, Dept Paediat, Toronto, ON M5G 1X8, Canada

[2] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[3] McMaster Univ, Dept Chem Engn, Hamilton, ON L8S 4L7, Canada

来源：

CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2013年 / 27卷 / 05期

关键词：

Escherichia coli; Host response; Irritable bowel syndrome; Pathogenicity; Treatment; HEMOLYTIC-UREMIC SYNDROME; SHIGA-TOXIN; INBORN-ERRORS; IFN-GAMMA; DIARRHEA; PATHOGENESIS; PHOSPHORYLATION; CYTOTOXIN; OUTBREAKS; CHILDREN;

D O I：

10.1155/2013/138673

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Enterohemorrhagic Escherichia coli serotype O157:H7 is a food- and waterborne pathogen that causes significant morbidity and mortality in both developing and industrialized nations. The present review focuses on the history, epidemiology and evolution of the pathogen; provides a mechanistic overview of major virulence factors (including Shiga toxins, locus of enterocyte effacement pathogenicity island and pO157 plasmid); discusses host immune responses to infection; considers available animal models; and provides an overview of current and potential future management considerations.

引用

页码：281 / 285

页数：5

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