The Role of NSAIDs in Breast Cancer Prevention and Relapse: Current Evidence and Future Perspectives

被引：46
作者：
Moris, Demetrios [1 ]
Kontos, Michalis [1 ]
Spartalis, Eleftherios [1 ]
Fentiman, Ian S. [2 ]
机构：
[1] Univ Athens, Dept Surg 1, Laikon Gen Hosp, Agiou Thoma 17, Athens 11527, Greece
[2] Guys Hosp, Res Oncol, Bermondsey Wing, London, England
来源：
BREAST CARE | 2016年 / 11卷 / 05期
关键词：
NSAIDs; Breast cancer; Aspirin; Hormone receptors; Prevention; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; REGULAR ASPIRIN USE; AGO RECOMMENDATIONS; RISK; CYCLOOXYGENASE-2; ASSOCIATION; EXPRESSION; SURVIVAL; INHIBITORS; AROMATASE;
D O I：
10.1159/000452315
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) have received considerable interest as potential chemopreventive agents. The aim of this review is to summarize the accumulated knowledge on the effect of NSAIDs on breast cancer incidence and natural history, and the underlying pathophysiology. NSAIDs mainly block inflammation by inhibiting cyclooxygenase enzymes, leading to lower prostaglandin synthesis. The latter has been reported to affect breast cancer risk through hormonal and inflammation-related pathways. Intensity, dose, frequency, duration, and timing of administration may also be significant. There is currently enough evidence to support a role of NSAIDs in breast cancer prevention and relapse, which deserves further large-scale experimental and clinical investigation. (C) 2016 S. Karger GmbH, Freiburg
引用
收藏
页码：339 / 344
页数：6
相关论文
共 50 条
[41]   Mangosteen for malignancy prevention and intervention: Current evidence, molecular mechanisms, and future perspectives [J].
Kalick, Lindsay S. ;
Khan, Hamaad A. ;
Maung, Erica ;
Baez, Yasmany ;
Atkinson, Alexa N. ;
Wallace, Carly E. ;
Day, Faith ;
Delgadillo, Blake E. ;
Mondal, Arijit ;
Watanapokasin, Ramida ;
Barbalho, Sandra M. ;
Bishayee, Anupam .
PHARMACOLOGICAL RESEARCH, 2023, 188
[42]   CDK4/6 blockade in breast cancer: current experience and future perspectives [J].
Zardavas, Dimitrios ;
Ponde, Noam ;
Tryfonidis, Konstantinos .
EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2017, 26 (12) :1357-1372
[43]   Metformin and Breast Cancer: Current Findings and Future Perspectives from Preclinical and Clinical Studies [J].
Corleto, Karen A. ;
Strandmo, Jenna L. ;
Giles, Erin D. .
PHARMACEUTICALS, 2024, 17 (03)
[44]   The Role of miRNA in Testicular Cancer: Current Insights and Future Perspectives [J].
Ditonno, Francesco ;
Franco, Antonio ;
Manfredi, Celeste ;
Fasanella, Daniela ;
Abate, Marco ;
La Rocca, Roberto ;
Crocerossa, Fabio ;
Iossa, Vincenzo ;
Falagario, Ugo Giovanni ;
Cirillo, Luigi ;
Altieri, Vincenzo Maria ;
Di Mauro, Ernesto ;
Crocetto, Felice ;
Barone, Biagio ;
Cilio, Simone ;
Pandolfo, Savio Domenico ;
Aveta, Achille ;
Mirone, Vincenzo ;
Franzese, Corrado Aniello ;
Arcaniolo, Davide ;
Napolitano, Luigi ;
Lee, Joo Yong .
MEDICINA-LITHUANIA, 2023, 59 (11)
[45]   Role of vitamins in the risk, prevention, and treatment of breast cancer [J].
Zhang, SMM .
CURRENT OPINION IN OBSTETRICS & GYNECOLOGY, 2004, 16 (01) :19-25
[46]   The role of breastfeeding in breast cancer prevention: a literature review [J].
Chen, Yulong ;
Jiang, Pengli ;
Geng, Yongqin .
FRONTIERS IN ONCOLOGY, 2023, 13
[47]   The Role of Biomarkers in Adrenocortical Carcinoma: A Review of Current Evidence and Future Perspectives [J].
Mizdrak, Maja ;
Ticinovic Kurir, Tina ;
Bozic, Josko .
BIOMEDICINES, 2021, 9 (02) :1-29
[48]   Colorectal Cancer: Current Updates and Future Perspectives [J].
Marcellinaro, Rosa ;
Spoletini, Domenico ;
Grieco, Michele ;
Avella, Pasquale ;
Cappuccio, Micaela ;
Troiano, Raffaele ;
Lisi, Giorgio ;
Garbarino, Giovanni M. ;
Carlini, Massimo .
JOURNAL OF CLINICAL MEDICINE, 2024, 13 (01)
[49]   Treatment for the endocrine resistant breast cancer: Current options and future perspectives [J].
Liu, Chun-Yu ;
Wu, Chia-Yun ;
Petrossian, Karineh ;
Huang, Tzu-Ting ;
Tseng, Ling-Ming ;
Chen, Shiuan .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2017, 172 :166-175
[50]   Current challenges and future perspectives of radiotherapy for locally advanced breast cancer [J].
Ghiam, Alireza Fotouhi ;
Spayne, Jacqueline ;
Lee, Justin .
CURRENT OPINION IN SUPPORTIVE AND PALLIATIVE CARE, 2014, 8 (01) :46-52
12345