The Role of NSAIDs in Breast Cancer Prevention and Relapse: Current Evidence and Future Perspectives

被引：45
|
作者：
Moris, Demetrios [1 ]
Kontos, Michalis [1 ]
Spartalis, Eleftherios [1 ]
Fentiman, Ian S. [2 ]
机构：
[1] Univ Athens, Dept Surg 1, Laikon Gen Hosp, Agiou Thoma 17, Athens 11527, Greece
[2] Guys Hosp, Res Oncol, Bermondsey Wing, London, England
来源：
BREAST CARE | 2016年 / 11卷 / 05期
关键词：
NSAIDs; Breast cancer; Aspirin; Hormone receptors; Prevention; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; REGULAR ASPIRIN USE; AGO RECOMMENDATIONS; RISK; CYCLOOXYGENASE-2; ASSOCIATION; EXPRESSION; SURVIVAL; INHIBITORS; AROMATASE;
D O I：
10.1159/000452315
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) have received considerable interest as potential chemopreventive agents. The aim of this review is to summarize the accumulated knowledge on the effect of NSAIDs on breast cancer incidence and natural history, and the underlying pathophysiology. NSAIDs mainly block inflammation by inhibiting cyclooxygenase enzymes, leading to lower prostaglandin synthesis. The latter has been reported to affect breast cancer risk through hormonal and inflammation-related pathways. Intensity, dose, frequency, duration, and timing of administration may also be significant. There is currently enough evidence to support a role of NSAIDs in breast cancer prevention and relapse, which deserves further large-scale experimental and clinical investigation. (C) 2016 S. Karger GmbH, Freiburg
引用
收藏
页码：339 / 344
页数：6
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