Consumption of Interesterified Medium- and Long-Chain Triacylglycerols Improves Lipid Metabolism and Reduces Inflammation in High-Fat Diet-Induced Obese Rats

被引：39

作者：

Du, Ying-Xue ^{[1
]}

Chen, Sun-Ni ^{[1
]}

Zhu, Hong-Lin ^{[1
]}

Niu, Xian ^{[1
]}

Li, Jing ^{[1
]}

Fan, Ya-Wei ^{[1
]}

Deng, Ze-Yuan ^{[1
]}

机构：

[1] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2020年 / 68卷 / 31期

基金：

中国国家自然科学基金;

关键词：

medium- and long-chain triacylglycerols; anti-obesity; lipid metabolism; inflammation; STRUCTURED MEDIUM-CHAIN; GUT MICROBIOTA; BODY-FAT; INSULIN-RESISTANCE; LIVER-DISEASE; FISH-OIL; A-I; ACIDS; TRIGLYCERIDES; SERUM;

D O I：

10.1021/acs.jafc.0c03103

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Medium- and long-chain triacylglycerols (MLCTs) were synthesized from rapeseed oil (RO), one kind of commonly used edible long-chain triacylglycerols (TGs), and then delivered to high-fat diet (HFD)-induced obese rats. Compared with RO, MLCT consumption exhibited more potent effects on reducing body and tissue weight gains, plasma TG, and total cholesterol (TC) levels and on improving hepatic TG, TC, fatty acid synthase, acetyl-CoA carboxylase, and lipoprteinlipase contents. Meanwhile, lower amounts of tumor necrosis factor-alpha (TNF-alpha), monocyte chemoattractant protein-1, and endotoxin in plasma, lower levels of interleukin-6 and TNF-alpha, and higher levels of interleukin-10 in both livers and white adipose tissues were detected in MLCT-fed rats. MLCT intake also remarkably suppressed the size of adipocytes and the number of macrophages. In conclusion, our study suggested that the interesterified MLCT was more efficacious in improving the lipid metabolism and inflammation in HFD-induced obese rats than RO.

引用

页码：8255 / 8262

页数：8

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