MicroRNAs in cancer: from developmental genes in worms to their clinical application in patients

被引：176

作者：

Pichler, M. ^{[1
,2
]}

Calin, G. A. ^{[1
,3
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA

[2] Med Univ Graz, Div Oncol, Graz, Austria

[3] Univ Texas MD Anderson Canc Ctr, Ctr RNA Interference & Noncoding RNAs, Houston, TX 77030 USA

来源：

BRITISH JOURNAL OF CANCER | 2015年 / 113卷 / 04期

基金：

奥地利科学基金会;

关键词：

microRNAs; diagnosis; prognosis; treatment; worms; cancer; DIAGNOSTIC ASSAY; LUNG-CANCER; EXPRESSION; CLASSIFICATION; PROGNOSIS; VALIDATION; BIOMARKERS;

D O I：

10.1038/bjc.2015.253

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Several discoveries have paved the way to personalise cancer medicine and a tremendous gain of knowledge in genomics and molecular mechanisms of cancer progression cumulated over the last years. Big stories in biology commonly start in a simple model system. No wonder microRNAs have been identified as regulators of embryonic development in the nematode Caenorhabditis elegans. From the first identification in worms to the first-in-man microRNA-based clinical trial in humans, almost 20 years passed. In this review we follow the story of understanding microRNA alterations in cancer, describe recent developments in the microRNA field and critically discuss their potential as diagnostic, prognostic and therapeutics factors in cancer medicine. We will explain the rationale behind the use of microRNAs in cancer diagnosis and prognosis prediction, but also discuss the limitations and pitfalls associated with this. Novel developments of combined microRNA/siRNA pharmacological approaches will be discussed and most recently data about MXR34, the first-tested microRNA drug will be described.

引用

页码：569 / 573

页数：5

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