Epidermal Growth Factor Receptor Inhibitors and Other Tyrosine Kinase Inhibitors for Solid Tumors

被引：0

作者：

Ruiz-Camps, Isabel ^{[1
]}

Aguilar-Company, Juan ^{[1
,2
]}

机构：

[1] Vall dHebron Univ Hosp, Infect Dis Dept, Passeig Vall dHebron 119-129, Barcelona 08035, Spain

[2] Vall dHebron Univ Hosp, Oncol Dept, Passeig Vall dHebron 119-129, Barcelona 08035, Spain

来源：

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA | 2020年 / 34卷 / 02期

关键词：

Kinase inhibitor; Targeted therapy; Immunosuppression; EGFR inhibitors; ALK inhibitors; mTOR inhibitors; BRAF/MEK inhibitors; VEGFR inhibitors; CELL LUNG-CANCER; OPEN-LABEL; 1ST-LINE TREATMENT; DOUBLE-BLIND; CHEMOTHERAPY; EVEROLIMUS; ERLOTINIB; RISK; EFFICACY; THERAPY;

D O I：

10.1016/j.idc.2020.02.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This article analyzes the risk of infection associated with small molecule kinase inhibitors used to treat solid organ malignancies and establishes specific recommendations. Most of these drugs are orally administered and have the ability to inhibit distinct kinases, which play a major role in cancer initiation and progression. Although the true extent of adverse events is not yet known, risk of infection does not seem to be a major problem with these drugs. Because of the limited clinical experience and the constant evolution of targeted therapies, recommendations may evolve in the near future.

引用

页码：257 / +

页数：15

共 68 条

[1] ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Cell surface receptors and associated signaling pathways) [J].

Aguilar-Company, J. ;

Fernandez-Ruiz, M. ;

Garcia-Campelo, R. ;

Garrido-Castro, A. C. ;

Ruiz-Camps, I. .

CLINICAL MICROBIOLOGY AND INFECTION, 2018, 24 :S41-S52

[2] Incidence and management of mTOR inhibitor-associated pneumonitis in patients with metastatic renal cell carcinoma [J].

Albiges, L. ;

Chamming's, F. ;

Duclos, B. ;

Stern, M. ;

Motzer, R. J. ;

Ravaud, A. ;

Camus, P. .

ANNALS OF ONCOLOGY, 2012, 23 (08) :1943-1953

[3] Folliculitis Induced by EGFR Inhibitors, Preventive and Curative Efficacy of Tetracyclines in the Management and Incidence Rates According to the Type of EGFR Inhibitor Administered: A Systematic Literature Review [J].

Bachet, Jean-Baptiste ;

Peuvrel, Lucie ;

Bachmeyer, Claude ;

Reguiai, Ziad ;

Gourraud, Pierre A. ;

Bouche, Olivier ;

Ychou, Marc ;

Bensadoun, Rene J. ;

Dreno, Brigitte ;

Andre, Thierry .

ONCOLOGIST, 2012, 17 (04) :555-568

[4] Kinase-targeted cancer therapies: progress, challenges and future directions [J].

Bhullar, Khushwant S. ;

Orrego Lagaron, Naiara ;

McGowan, Eileen M. ;

Parmar, Indu ;

Jha, Amitabh ;

Hubbard, Basil P. ;

Rupasinghe, H. P. Vasantha .

MOLECULAR CANCER, 2018, 17

[5] Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial [J].

Bruix, Jordi ;

Qin, Shukui ;

Merle, Philippe ;

Granito, Alessandro ;

Huang, Yi-Hsiang ;

Bodoky, Gyrogy ;

Pracht, Marc ;

Yokosuka, Osamu ;

Rosmorduc, Olivier ;

Breder, Valeriy ;

Gerolami, Rene ;

Masi, Gianluca ;

Ross, Paul J. ;

Song, Tianqiang ;

Bronowicki, Jean-Pierre ;

Ollivier-Hourmand, Isabelle ;

Kudo, Masatoshi ;

Cheng, Ann-Lii ;

Llovet, Josep M. ;

Finn, Richard S. ;

LeBerre, Marie-Aude ;

Baumhauer, Annette ;

Meinhardt, Gerold ;

Han, Guohong .

LANCET, 2017, 389 (10064) :56-66

[6] Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases [J].

Burgel, P-R. ;

Nadel, J. A. .

EUROPEAN RESPIRATORY JOURNAL, 2008, 32 (04) :1068-1081

[7] Pneumocystis jirovecii pneumonia under everolimus in two patients with metastatic pancreatic neuroendocrine tumors [J].

Carbonnaux, Melodie ;

Molin, Yann ;

Souquet, Pierre-Jean ;

Tantin, Arnaud ;

Lombard-Bohas, Catherine ;

Walter, Thomas .

INVESTIGATIONAL NEW DRUGS, 2014, 32 (06) :1308-1310

[8] Subacute Invasive Aspergillosis Associated With Sorafenib Therapy for Hepatocellular Carcinoma Reply [J].

Chamilos, Georgios ;

Lionakis, Michail S. ;

Kontoyiannis, Dimitrios P. .

CLINICAL INFECTIOUS DISEASES, 2018, 67 (01) :157-159

[9] Call for Action: Invasive Fungal Infections Associated With Ibrutinib and Other Small Molecule Kinase Inhibitors Targeting Immune Signaling Pathways [J].

Chamilos, Georgios ;

Lionakis, Michail S. ;

Kontoyiannis, Dimitrios P. .

CLINICAL INFECTIOUS DISEASES, 2018, 66 (01) :140-148

[10] Cabozantinib versus everolimus in advanced renal cell carcinoma (METEOR): final results from a randomised, open-label, phase 3 trial [J].

Choueiri, Toni K. ;

Escudier, Bernard ;

Powles, Thomas ;

Tannir, Nizar M. ;

Mainwaring, Paul N. ;

Rini, Brian I. ;

Hammers, Hans J. ;

Donskov, Frede ;

Roth, Bruce J. ;

Peltola, Katriina ;

Lee, Jae Lyun ;

Heng, Daniel Y. C. ;

Schmidinger, Manuela ;

Agarwal, Neeraj ;

Sternberg, Cora N. ;

McDermott, David F. ;

Aftab, Dana T. ;

Hessel, Colin ;

Old, Christian Scheff ;

Schwab, Gisela ;

Hutson, Thomas E. ;

Pal, Sumanta ;

Motzer, Robert J. .

LANCET ONCOLOGY, 2016, 17 (07) :917-927

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