Coagulopathy in COVID-19 and anticoagulation clinical trials

被引：7

作者：

Zhang, Heng ^{[1
]}

Lao, Qifang ^{[1
,3
]}

Zhang, Jue ^{[1
]}

Zhu, Jieqing ^{[1
,2
]}

机构：

[1] Versiti Blood Ctr Wisconsin, Blood Res Inst, Milwaukee, WI 53226 USA

[2] Med Coll Wisconsin, Dept Biochem, Milwaukee, WI USA

[3] Guangxi Med Univ, Dept Crit Care Med, Canc Hosp, Nanning, Guangxi, Peoples R China

来源：

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2022年 / 35卷 / 03期

关键词：

COVID-19; Coagulopathy; CAC; Endotheliitis; NETs; HOSPITALIZED-PATIENTS; PROPHYLACTIC ANTICOAGULATION; OPEN-LABEL; THROMBOSIS; TOCILIZUMAB; COLCHICINE; PLATELETS; SUPPORT;

D O I：

10.1016/j.beha.2022.101377

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Severe acute respiratory disease coronavirus 2 (SARS-COV-2) first emerged in Wuhan, China, in December 2019 and has caused a global pandemic of a scale unprecedented in the modern era. People infected with SARS-CoV-2 can be asymptomatic, moderate symptomatic or develop severe COVID-19. Other than the typical acute respiratory distress syndrome (ARDS), patients with moderate or severe COVID-19 also develop a distinctive systemic coagulopathy, known as COVID19-associated coagulopathy (CAC), which is different from sepsis-related forms of disseminated intravascular coagulation (DIC). Endotheliopathy or endotheliitis are other unique features of CAC. The endothelial cell perturbation can further increase the risk of thrombotic events in COVID-19 patients. In this review, we will summarize the current knowledge on COVID-19 coagulopathy and the possible mechanisms for the condition. We also discuss the results of clinical trials testing methods for mitigating thrombosis events in COVID-19 patients.

引用

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