A systematic review of sugammadex vs neostigmine for reversal of neuromuscular blockade

被引：117

作者：

Abad-Gurumeta, A. ^{[1
]}

Ripolles-Melchor, J. ^{[2
]}

Casans-Frances, R. ^{[3
]}

Espinosa, A. ^{[4
]}

Martinez-Hurtado, E. ^{[2
]}

Fernandez-Perez, C. ^{[5
]}

Ramirez, J. M. ^{[6
]}

Lopez-Timoneda, F. ^{[7
]}

Calvo-Vecino, J. M. ^{[2
]}

机构：

[1] Hosp Univ la Paz, Dept Anaesthesia, Madrid, Spain

[2] Univ Complutense Madrid, Hosp Univ Infanta Leonor, Dept Anaesthesia, Madrid, Spain

[3] Hosp Clin Univ Lozano Blesa, Dept Anaesthesia, Zaragoza, Spain

[4] Orebro Univ Hosp, Dept Anaesthesia, Orebro, Sweden

[5] Univ Complutense Madrid, Dept Consultant Prevent Med & Publ Hlth, Madrid, Spain

[6] Univ Zaragoza, Dept Colorectal Surg, Zaragoza, Spain

[7] Univ Complutense Madrid, Hosp Clin San Carlos, Dept Anaesthesia, Madrid, Spain

来源：

ANAESTHESIA | 2015年 / 70卷 / 12期

关键词：

TRIAL SEQUENTIAL-ANALYSIS; ADDUCTOR POLLICIS MUSCLE; CLINICAL-SIGNIFICANCE; RESPIRATORY EVENTS; BLOCKING-AGENTS; RECOVERY; RISK; METAANALYSES; THRESHOLDS; SURGERY;

D O I：

10.1111/anae.13277

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

We reviewed systematically sugammadex vs neostigmine for reversing neuromuscular blockade. We included 17 randomised controlled trials with 1553 participants. Sugammadex reduced all signs of residual postoperative paralysis, relative risk (95% CI) 0.46 (0.29-0.71), p=0.0004 and minor respiratory events, relative risk (95% CI) 0.51 (0.32-0.80), p=0.0034. There was no difference in critical respiratory events, relative risk (95% CI) 0.13 (0.02-1.06), p=0.06. Sugammadex reduced drug-related side-effects, relative risk (95% CI) 0.72 (0.54-0.95), p=0.02. There was no difference in the rate of postoperative nausea or the rate of postoperative vomiting, relative risk (95% CI) 0.94 (0.79-1.13), p=0.53, and 0.87 (0.65-1.17), p=0.36 respectively.

引用

页码：1441 / 1452

页数：12

共 55 条

[1] Intraoperative reversal of neuromuscular block with sugammadex or neostigmine during extreme lateral interbody fusion, a novel technique for spine surgery [J].