Phenolic composition, antioxidant and antinociceptive activities of Syringa vulgaris L. bark and leaf extracts

被引:19
作者
Varga, Erzsebet [1 ]
Barabas, Csenge [1 ]
Toth, Anita [2 ]
Boldizsar, Imre [3 ]
Noszal, Bela [4 ]
Toth, Gergo [4 ]
机构
[1] Univ Med & Pharm, Dept Pharmacognosy & Phytotherapy, Targu Mures, Romania
[2] Semmelweis Univ, Dept Pharmacognosy, Budapest, Hungary
[3] Eotvos Lorand Univ, Inst Biol, Dept Plant Anat, Budapest, Hungary
[4] Semmelweis Univ, Dept Pharmaceut Chem, Budapest, Hungary
关键词
Phenolic profiling; Syringa vulgaris; oleuropein; antioxidant activity; antinociceptive activity; GLUCOSIDES;
D O I
10.1080/14786419.2018.1425855
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Metabolite profile, antioxidant and antinociceptive activities of Syringa vulgaris bark and leaf methanolic extracts were investigated. By means of HPLC-DAD-ESI-TOF and HPLC-DAD-ESI-MS/MS, a total of 33 phenolics were identified, including 15 secoiridoids, 6 phenylpropanoids, 3 flavonoids, 3 lignans and 6 low molecular weight phenols. Validated quantitative analysis show that syringin (2.52%) and rutin (1.13%) are the main phenolic compounds in bark and leaf, respectively. Notable radical scavenging and antinociceptive activities of the bark and leaf extracts were confirmed by in vitro DPPHBLACK CIRCLE and ABTS(BLACK CIRCLE+) assays and by in vivo hot-plate method in mice, respectively. Our results could lay the scientific basic of future clinical perspectives of lilac bark and leaf. [GRAPHICS] .
引用
收藏
页码:1664 / 1669
页数:6
相关论文
共 16 条
[1]   HYPOTENSIVE ACTION OF SYRINGIN FROM SYRINGA-VULGARIS [J].
AHMAD, M ;
AFTAB, K .
PHYTOTHERAPY RESEARCH, 1995, 9 (06) :452-454
[2]  
AHMAD M, 1987, Pakistan Journal of Scientific and Industrial Research, V30, P150
[3]   Antinociceptive activity of Quillaja saponaria Mol. saponin extract, quillaic acid and derivatives in mice [J].
Arrau, Sylvia ;
Delporte, Carla ;
Cartagena, Carlos ;
Rodriguez-Diaz, Maite ;
Gonzalez, Patricia ;
Silva, Ximena ;
Cassels, Bruce K. ;
Miranda, Hugo F. .
JOURNAL OF ETHNOPHARMACOLOGY, 2011, 133 (01) :164-167
[4]  
Berbecaru-Iovan A, 2016, FARMACIA, V64, P722
[5]   Secoiridoid glucosides and related compounds from Syringa reticulata and their antioxidant activities [J].
Bi, Xueyan ;
Li, Wei ;
Sasaki, Tatsunori ;
Li, Qin ;
Mitsuhata, Naoko ;
Asada, Yoshihisa ;
Zhang, Qingbo ;
Koike, Kazuo .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (21) :6426-6429
[6]   Olive (Olea europaea L.) leaf extract elicits antinociceptive activity, potentiates morphine analgesia and suppresses morphine hyperalgesia in rats [J].
Esmaeili-Mahani, Saeed ;
Rezaeezadeh-Roukerd, Maryam ;
Esmaeilpour, Khadije ;
Abbasnejad, Mehdi ;
Rasoulian, Bahram ;
Sheibani, Vahid ;
Kaeidi, Ayat ;
Hajializadeh, Zahra .
JOURNAL OF ETHNOPHARMACOLOGY, 2010, 132 (01) :200-205
[7]  
Ezeja MI, 2011, ANN MED HEALTH SCI R, V1, P55
[8]   COMPOSITION AND ANTIRADICAL ACTIVITY OF LILAC EXTRACTS [J].
Fedoseeva, A. A. ;
Lebedkova, O. S. ;
Kanibolotskaya, L. V. ;
Shendrik, A. N. ;
Dudzinskaya, V. V. ;
Tkachenko, L. N. ;
Shineva, N. V. .
PHARMACEUTICAL CHEMISTRY JOURNAL, 2011, 45 (02) :91-92
[9]   Qualitative screening of phenolic compounds in olive leaf extracts by hyphenated liquid chromatography and preliminary evaluation of cytotoxic activity against human breast cancer cells [J].
Fu, Shaoping ;
Arraez-Roman, David ;
Segura-Carretero, Antonio ;
Menendez, Javier A. ;
Menendez-Gutierrez, Maria P. ;
Micol, Vicente ;
Fernandez-Gutierrez, Alberto .
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2010, 397 (02) :643-654
[10]   Antioxidative glucosides from the fruits of Ligustrum lucidum [J].
He, ZD ;
But, PPH ;
Chan, TWD ;
Dong, H ;
Xu, HX ;
Lau, CP ;
Sun, HD .
CHEMICAL & PHARMACEUTICAL BULLETIN, 2001, 49 (06) :780-784