Phenolic composition, antioxidant and antinociceptive activities of Syringa vulgaris L. bark and leaf extracts

被引：19

作者：

Varga, Erzsebet ^{[1
]}

Barabas, Csenge ^{[1
]}

Toth, Anita ^{[2
]}

Boldizsar, Imre ^{[3
]}

Noszal, Bela ^{[4
]}

Toth, Gergo ^{[4
]}

机构：

[1] Univ Med & Pharm, Dept Pharmacognosy & Phytotherapy, Targu Mures, Romania

[2] Semmelweis Univ, Dept Pharmacognosy, Budapest, Hungary

[3] Eotvos Lorand Univ, Inst Biol, Dept Plant Anat, Budapest, Hungary

[4] Semmelweis Univ, Dept Pharmaceut Chem, Budapest, Hungary

来源：

NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 11期

关键词：

Phenolic profiling; Syringa vulgaris; oleuropein; antioxidant activity; antinociceptive activity; GLUCOSIDES;

D O I：

10.1080/14786419.2018.1425855

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Metabolite profile, antioxidant and antinociceptive activities of Syringa vulgaris bark and leaf methanolic extracts were investigated. By means of HPLC-DAD-ESI-TOF and HPLC-DAD-ESI-MS/MS, a total of 33 phenolics were identified, including 15 secoiridoids, 6 phenylpropanoids, 3 flavonoids, 3 lignans and 6 low molecular weight phenols. Validated quantitative analysis show that syringin (2.52%) and rutin (1.13%) are the main phenolic compounds in bark and leaf, respectively. Notable radical scavenging and antinociceptive activities of the bark and leaf extracts were confirmed by in vitro DPPHBLACK CIRCLE and ABTS(BLACK CIRCLE+) assays and by in vivo hot-plate method in mice, respectively. Our results could lay the scientific basic of future clinical perspectives of lilac bark and leaf. [GRAPHICS] .

引用

页码：1664 / 1669

页数：6

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