Two Novel Salts of Tris(hydroxymethyl)aminomethane (THAM): Synthesis, Crystal Structure, Thermal and Hirshfeld Surfaces Analysis

The crystals of two organic salts of tris(hydroxymethyl)aminomethane (THAM) with p-hydroxybenzoic acid (PHBA) and salicylic acid (SA) were obtained. Their crystal structures were characterized by single-crystal X-ray diffraction, IR spectra, differential scanning calorimetry, thermogravimetric analyses and hot stage microscopy. Wherein, 1 forms a 1:1 (THAM:PHBA) salt, and 2 forms a 2:2:1 (THAM:SA:H2O) salt. The structure determination shows that the two salts are all primarily stabilized by strong O center dot center dot center dot H hydrogen bonds interaction between THAM and the two acids. The Hirshfeld surfaces and fingerprint plots of the reported salts were prepared and analyzed and reveal that the structures are stabilized by O center dot center dot center dot H, H center dot center dot center dot H, C center dot center dot center dot H, O center dot center dot center dot O and O center dot center dot center dot C intermolecular interactions. The paper is about synthesis, crystal structure, thermal and Hirshfeld surfaces analysis of two THAM salts.