Early phase clinical trials-are dose expansion cohorts needed?

被引：23
|
作者：
Iasonos, Alexia [1 ]
O'Quigley, John [2 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10065 USA
[2] Univ Paris 06, F-75005 Paris, France
来源：
NATURE REVIEWS CLINICAL ONCOLOGY | 2015年 / 12卷 / 11期
关键词：
I TRIALS; DESIGN; CANCER; SAFETY;
D O I：
10.1038/nrclinonc.2015.174
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Dose-expansion cohorts (DECs) enable investigators to identify potentially effective drugs, for specific patient populations, in a single trial by assessing antitumour activity as early as possible. We discuss how the objectives, design and interpretation of DEC have evolved, and how DECs are changing the landscape of early drug development.
引用
收藏
页码：626 / 628
页数：2
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