Alcohol addiction: toward a patient-oriented pharmacological treatment

被引:10
作者
Addolorato, Giovanni [1 ]
Mirijello, Antonio [1 ]
Leggio, Lorenzo [2 ,3 ,4 ]
机构
[1] Univ Cattolica Sacro Cuore, Dept Internal Med, Gemelli Hosp, I-00168 Rome, Italy
[2] NIAAA, Sect Clin Psychoneuroendocrinol & Neuropsychophar, Lab Clin & Translat Studies, NIH, Bethesda, MD USA
[3] NIDA, Intramural Res Program, NIH, Baltimore, MD USA
[4] Brown Univ, Dept Behav & Social Sci, Providence, RI 02912 USA
关键词
alcohol use disorder; drug treatment; NALTREXONE RESPONSE; DOUBLE-BLIND; BACLOFEN; SAFETY; ONDANSETRON; DEPENDENCE; ABSTINENCE; EFFICACY;
D O I
10.1517/14656566.2013.834047
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Very few medications (i.e., disulfiram, naltrexone and acamprosate) are approved for the treatment of alcoholism and their effects are suboptimal. The development of new effective and safe pharmacological agents to treat alcoholic patients is crucial, together with the need to identify predictors of outcomes in different subsets of patients.
引用
收藏
页码:2157 / 2160
页数:4
相关论文
共 14 条
[1]   Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study [J].
Addolorato, Giovanni ;
Leggio, Lorenzo ;
Ferrulli, Anna ;
Cardone, Silvia ;
Vonghia, Luisa ;
Mirijello, Antonio ;
Abenavoli, Ludovico ;
D'Angelo, Cristina ;
Caputo, Fabio ;
Zambon, Antonella ;
Haber, Paul S. ;
Gasbarrini, Giovanni .
LANCET, 2007, 370 (9603) :1915-1922
[2]   Management of Alcohol Dependence in Patients with Liver Disease [J].
Addolorato, Giovanni ;
Mirijello, Antonio ;
Leggio, Lorenzo ;
Ferrulli, Anna ;
Landolfi, Raffaele .
CNS DRUGS, 2013, 27 (04) :287-299
[3]   Safety and Efficacy of Baclofen in the Treatment of Alcohol-Dependent Patients [J].
Addolorato, Giovanni ;
Leggio, Lorenzo .
CURRENT PHARMACEUTICAL DESIGN, 2010, 16 (19) :2113-2117
[4]   An evaluation of μ-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence [J].
Anton, Raymond F. ;
Oroszi, Gabor ;
O'Malley, Stephanie ;
Couper, David ;
Swift, Robert ;
Pettinati, Helen ;
Goldman, David .
ARCHIVES OF GENERAL PSYCHIATRY, 2008, 65 (02) :135-144
[5]   The Declining Efficacy of Naltrexone Pharmacotherapy for Alcohol Use Disorders Over Time: A Multivariate Meta-Analysis [J].
Del Re, A. C. ;
Maisel, Natalya ;
Blodgett, Janet ;
Finney, John .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2013, 37 (06) :1064-1068
[6]   Efficacy and Safety of Baclofen for Alcohol Dependence: A Randomized, Double-Blind, Placebo-Controlled Trial [J].
Garbutt, James C. ;
Kampov-Polevoy, Alexei B. ;
Gallop, Robert ;
Kalka-Juhl, Linda ;
Flannery, Barbara A. .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2010, 34 (11) :1849-1857
[7]   Ondansetron for reduction of drinking among biologically predisposed alcoholic patients - A randomized controlled trial [J].
Johnson, BA ;
Roache, JD ;
Javors, MA ;
DiClemente, CC ;
Cloninger, CR ;
Prihoda, TJ ;
Bordnick, PS ;
Ait-Daoud, N ;
Hensler, J .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 284 (08) :963-971
[8]   Pharmacogenetic Approach at the Serotonin Transporter Gene as a Method of Reducing the Severity of Alcohol Drinking [J].
Johnson, Bankole A. ;
Ait-Daoud, Nassima ;
Seneviratne, Chamindi ;
Roache, John D. ;
Javors, Martin A. ;
Wang, Xin-Qun ;
Liu, Lei ;
Penberthy, J. Kim ;
DiClemente, Carlo C. ;
Li, Ming D. .
AMERICAN JOURNAL OF PSYCHIATRY, 2011, 168 (03) :265-275
[9]   A Within-Group Design of Nontreatment Seeking 5-HTTLPR Genotyped Alcohol-Dependent Subjects Receiving Ondansetron and Sertraline [J].
Kenna, George A. ;
Zywiak, William H. ;
McGeary, John E. ;
Leggio, Lorenzo ;
McGeary, Chinatsu ;
Wang, Shirley ;
Grenga, Andrea ;
Swift, Robert M. .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2009, 33 (02) :315-323
[10]   Pharmacological relapse prevention of alcoholism: Clinical predictors of outcome [J].
Kiefer, F ;
Helwig, H ;
Tarnaske, T ;
Otte, C ;
Jahn, H ;
Wiedemann, K .
EUROPEAN ADDICTION RESEARCH, 2005, 11 (02) :83-91