Copper-catalyzed chemoselective C-H functionalization of quinoxalin-2(1H)-ones with hexafluoroisopropanol

被引：26

作者：

Su, Hai-Yan ^{[1
]}

Zhu, Xiao-Lei ^{[1
]}

Huang, Yangen ^{[1
]}

Xu, Xiu-Hua ^{[2
]}

Qing, Feng-Ling ^{[1
,2
]}

机构：

[1] Donghua Univ, Coll Chem Chem Engn & Biotechnol, 2999 North Renmin Lu, Shanghai 201620, Peoples R China

[2] Chinese Acad Sci, Key Lab Organofluorine Chem, Ctr Excellence Mol Synth, Shanghai Inst Organ Chem,Univ Chinese Acad Sci, 345 Lingling Lu, Shanghai 200032, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 84期

基金：

中国国家自然科学基金;

关键词：

FLUORINATED ALCOHOLS; QUINOXALINONES; PHOTOCATALYST; ALKOXYLATION; DERIVATIVES; INHIBITORS; ARYLATION; THIOLS;

D O I：

10.1039/d0cc05623e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An unexpected three-component reaction of quinoxalin-2(1H)-ones,tert-butyl peroxybenzoate (TBPB), and hexafluoroisopropanol (HFIP) is described. Under CuBr-catalyzed and TBPB-oxidized conditions, a variety of hydroxyhexafluoroisobutylated quinoxalin-2(1H)-ones were formed. Furthermore, the first hexafluoroisopropoxylation of the quinoxalin-2(1H)-ones with HFIP is also demonstrated with Cu2O as the catalyst and PhI(OAc)(2)as the oxidant. These new transformations of HFIP furnish previously unknown and potentially useful fluorinated quinoxalin-2(1H)-one derivatives.

引用

页码：12805 / 12808

页数：4

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