Asymmetric hydrogenation of quinolines and isoquinolines activated by chloroformates

被引：279
|
作者：
Lu, SM [1 ]
Wang, YQ [1 ]
Han, XW [1 ]
Zhou, YG [1 ]
机构：
[1] Chinese Acad Sci, Dalian Inst Chem Phys, State Key lab Catalysis, Dalian 116023, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 14期
关键词：
asymmetric synthesis; chloroformates; enantioselectivity; hydrogenation; quinolines;
D O I：
10.1002/anie.200503073
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Active ingredient: Optically active tetrahydroquinolines and tetrahydroisoquinolines can be obtained by the asymmetric hydrogenation of quinolines and isoquinolines with chloroformates as the activating reagent (e.g., ClCO2Bn, see scheme). The method has been applied to the asymmetric synthesis of several naturally occurring alkaloids. Bn = benzyl. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：2260 / 2263
页数：4
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