Gut Microbiota, the Potential Biological Medicine for Prevention, Intervention and Drug Sensitization to Fight Diseases

被引:9
作者
Wu, Haijie [1 ]
Chen, Xiaoguang [1 ]
Zhang, Sen [1 ]
Li, Jiaxin [2 ,3 ]
机构
[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
[2] Wenzhou Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 6, Lishui 323000, Peoples R China
[3] Lishui City Peoples Hosp, Lishui 323000, Peoples R China
基金
北京市自然科学基金;
关键词
gut microbiota; Akkermansia; Bifidobacterium; Lactobacillus; Parabacteroides; cancer; neurodegenerative diseases; type II diabetes; kidney diseases; autism spectrum disorder; AKKERMANSIA-MUCINIPHILA; SPECTRUM; HOST; PHARMACOKINETICS; COLONIZATION; MECHANISMS; SYMPTOMS; IMMUNITY; OBESITY; AUTISM;
D O I
10.3390/nu14204220
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
As the largest "immune organ" of human beings, the gut microbiota is symbiotic and mutually beneficial with the human host, playing multiple physiological functions. Studies have long shown that dysbiosis of gut microbiota is associated with almost all human diseases, mainly including type II diabetes, cancers, neurodegenerative diseases, autism spectrum disorder, and kidney diseases. As a novel and potential biological medicine for disease prevention, intervention and drug sensitization, the gut microbiota has attracted more and more attention recently. Although the gut microbiota is a comprehensive microbial community, several star bacteria have emerged as possible tools to fight against various diseases. This review aims to elucidate the relevance of gut microbiota dysbiosis with disease occurrence and progression, and mainly summarizes four well-known genera with therapeutic and sensitizing potential, Akkermansia, Bifidobacterium, Lactobacillus and Parabacteroides, thoroughly elucidate their potential value as biological drugs to treat diverse disease.
引用
收藏
页数:13
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