Peptide Hydrogels Assembled from Nonionic Alkyl-polypeptide Amphiphiles Prepared by Ring-Opening Polymerization

被引:51
作者
Chen, Chongyi [1 ]
Wu, Decheng [1 ]
Fu, Wenxin [1 ]
Li, Zhibo [1 ]
机构
[1] Chinese Acad Sci, Beijing Natl Lab Mol Sci BNLMS, Lab Polymer Phys & Chem, Inst Chem, Beijing 100190, Peoples R China
基金
中国国家自然科学基金;
关键词
SECONDARY STRUCTURE ANALYSES; HYBRID BLOCK-COPOLYMERS; POLY(ETHYLENE GLYCOL); NANOFIBER HYDROGEL; PROTEIN; DELIVERY; DESIGN; FIBERS;
D O I
10.1021/bm4008259
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Three alkyl-polypeptide (AP) amphiphiles were prepared using ring-opening polymerization of alpha-amino acid N-carboxyanhydride. The polypeptide segment was composed of diethylene-glycol-monomethyl-ether-functionalized poly-L-glutamate (poly-L-EG(2)Glu). These AP amphiphiles can spontaneously self-assemble into transparent hydrogels in water. These hydrogels showed shear thinning properties, and their strength can be modulated by hydrophobic alkyl tails. CryoTEM and AFM characterizations suggested that these hydrogels were formed by nanoribbons arising from intermolecular interactions between nonionic poly-L-EG(2)Glu segments.
引用
收藏
页码:2494 / 2498
页数:5
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