Structural Basis of Human Serum Albumin and Its Complexes

被引：0
|
作者：
Yang Feng [1 ,2 ]
Liang Hong [1 ,2 ]
机构：
[1] Guangxi Normal Univ, Minist Sci & Technol China, State Key Lab Cultivat Base Chem & Mol Engn Med R, Guilin 541004, Peoples R China
[2] Guangxi Normal Univ, Sch Chem & Chem Engn, Guilin 541004, Peoples R China
来源：
PROGRESS IN CHEMISTRY | 2013年 / 25卷 / 04期
关键词：
human serum albumin; human serum albumin-drug complexes; protein crystal structure; X-ray crystallography; FATTY-ACID-BINDING; IRON PROTOPORPHYRIN-IX; CRYSTAL-STRUCTURE; CRYSTALLOGRAPHIC ANALYSIS; ATOMIC-STRUCTURE; LIGAND-BINDING; IIA SUBDOMAIN; DRUG-DRUG; AFFINITY; SITES;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Human serum albumin is the most abundant protein in plasma and one of the major binders/carriers of fatty acid and drugs, plays an essential role in pharmacokinetics and delivery of drugs for it transports a wide variety of drugs to target organs and tissues. In the past forty years, the interaction between albumin and compounds is research hotspots both at home and abroad. Furthermore, human serum albumin has been extensively studied as drug carrier. Therefore, this paper first reviews the knowledge on structure of human serum albumin and its complexes, and then puts forward some future challenges on human serum albumin field.
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收藏
页码：530 / 538
页数：9
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