High-density lipoprotein synthesis and metabolism (Review)

被引：57

作者：

Zhou, Lingyan ^{[1
]}

Li, Congcong ^{[1
]}

Gao, Ling ^{[1
,2
]}

Wang, Aihong ^{[3
]}

机构：

[1] Shandong Univ, Dept Endocrinol, Shandong Prov Hosp, Inst Endocrinol,Shandong Acad Clin Med, Jinan 250021, Shandong, Peoples R China

[2] Shandong Univ, Cent Lab, Shandong Prov Hosp, Jinan 250021, Shandong, Peoples R China

[3] Shandong Univ, Dept Cardiol, Shandong Prov Hosp, Jinan 250021, Shandong, Peoples R China

来源：

MOLECULAR MEDICINE REPORTS | 2015年 / 12卷 / 03期

关键词：

high-density lipoprotein; scavenger receptor class B type I; adenosine triphosphate-binding cassette sub-family A member 1; reverse cholesterol transport; B TYPE-I; ESTER TRANSFER PROTEIN; REVERSE CHOLESTEROL TRANSPORT; APOLIPOPROTEIN-A-I; SR-BI; MEDIATED CHOLESTEROL; TRANSGENIC MICE; RECEPTOR LXR; LIPID EFFLUX; BINDING;

D O I：

10.3892/mmr.2015.3930

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

High density lipoproteins (Hill.) are heterogeneous particles regarding their size and composition. They have vital functions in reverse cholesterol transport (RCT). RCT occurs when lipid-free apolipoprotein AI recruits cholesterol and phospholipid to form nascent HDL particles. Adenosine triphosphate-binding cassette transporters and scavenger receptor Class B type I were found to be associated with the synthesis of HDL. Experimental studies have identified several potential anti-atherogenic effects of HDL, including promotion of fliacrophage cholesterol outflow as well as anti-inflammatory and anti-thrombotic effects. HDL can also transport microRNAs. This review mainly summarizes the present knowledge of HDL synthesis and metabolism.

引用

页码：4015 / 4021

页数：7

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