Terminal alkynes from aldehydes via dehydrohalogenation of (Z)-1-iodo-1-alkenes with TBAF

被引：22

作者：

Beshai, Mira ^{[1
]}

Dhudshia, Bhartesh ^{[1
]}

Mills, Ryan ^{[1
]}

Thadani, Avinash N. ^{[1
]}

机构：

[1] Univ Windsor, Dept Chem & Biochem, Windsor, ON N9B 3P4, Canada

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 48期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Alkynes; Iodoalkenes; Dehydrohalogenation; TBAF;

D O I：

10.1016/j.tetlet.2008.09.060

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Terminal alkynes were prepared in near quantitative yields via dehydrohalogenation of (Z)-1-iodo-1-alkenes with tetrabutylammonium fluoride (TBAF) under mild conditions. The methodology was expanded to include a one-pot, direct synthesis of terminal alkynes from aldehydes Without the necessity of isolating and purifying the intermediate iodoalkene. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：6794 / 6796

页数：3

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