Hybrid Volatolomics and Disease Detection

被引：223

作者：

Broza, Yoav Y. ^{[1
,2
]}

Mochalski, Pawel ^{[3
,4
,5
]}

Ruzsanyi, Vera ^{[3
,4
,5
]}

Amann, Anton ^{[3
,4
,5
]}

Haick, Hossam ^{[1
,2
]}

机构：

[1] Technion Israel Inst Technol, Dept Chem Engn, IL-3200003 Haifa, Israel

[2] Technion Israel Inst Technol, Russell Berrie Nanotechnol Inst, IL-3200003 Haifa, Israel

[3] Univ Innsbruck, Breath Res Inst, A-6020 Innsbruck, Austria

[4] Univ Innsbruck, Univ Clin Anesthesia, A-6020 Innsbruck, Austria

[5] Med Univ Innsbruck, A-6020 Innsbruck, Austria

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 38期

基金：

比尔及梅琳达.盖茨基金会; 芬兰科学院; 奥地利科学基金会; 欧洲研究理事会;

关键词：

breath; diagnosis; skin; volatile organic compounds; volatolomics; VOLATILE ORGANIC-COMPOUNDS; AIR PARTITION-COEFFICIENTS; LUNG-CANCER CELLS; HUMAN-BODY ODOR; CHROMATOGRAPHY-MASS-SPECTROMETRY; SOLID-PHASE MICROEXTRACTION; BRONCHIAL EPITHELIAL-CELLS; EXHALED BREATH; IN-VITRO; GAS-CHROMATOGRAPHY;

D O I：

10.1002/anie.201500153

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This Review presents a concise, but not exhaustive, didactic overview of some of the main concepts and approaches related to "volatolomics"- an emerging frontier for fast, risk-free, and potentially inexpensive diagnostics. It attempts to review the source and characteristics of volatolomics through the so-called volatile organic compounds (VOCs) emanating from cells and their microenvironment. It also reviews the existence of VOCs in several bodily fluids, including the cellular environment, blood, breath, skin, feces, urine, and saliva. Finally, the usefulness of volatolomics for diagnosis from a single bodily fluid, as well as ways to improve these diagnostic aspects by "hybrid" approaches that combine VOC profiles collected from two or more bodily fluids, will be discussed. The perspectives of this approach in developing the field of diagnostics to a new level are highlighted.

引用

页码：11036 / 11048

页数：13

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