Interleukin (IL)-17;
neutrophil granulocyte;
Th17;
T cell;
D O I:
10.1684/ejd.2012.1854
中图分类号:
R75 [皮肤病学与性病学];
学科分类号:
100206 ;
摘要:
Background: Interleukin (IL)-17 is a key molecule for epithelial immunity and inflammation. Objectives: To quantify IL-17 expression in situ in a large panel of cutaneous diseases. Materials & Methods: 289 samples of the 30 most common cutaneous infectious, autoimmune, inflammatory and tumor diseases were stained for IL-17 immunohistochemically. Results: IL-17 expression strongly varied between the diseases, but was conserved within each disease. The major cellular sources of IL-17 were T cells and granulocytes. Skin diseases caused by extracellular microbials were infiltrated by many IL-17+ cells, while intracellular infections were scarcely positive for IL-17. While autoimmune diseases were mostly accompanied by IL-17+ T cells, IL-17+ granulocytes were dominant in neutrophilic dermatoses. Conclusion: Cutaneous diseases show a characteristic pattern of IL-17+ cellular infiltrate. These patterns are relevant for the clinician, since therapeutic approaches targeting differentiation of Th17 cells as well as direct targeting of IL-17 are or will become available.
机构:
Univ Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USAUniv Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
Fahmy, Marianne
Ramamoorthy, Sonia
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Inflammatory Bowel Dis, Dept Surg, La Jolla, CA USAUniv Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
Ramamoorthy, Sonia
Hata, Tissa
论文数: 0引用数: 0
h-index: 0
机构:
UC San Diego Hlth Syst, Div Dermatol, La Jolla, CA USAUniv Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
Hata, Tissa
Sandborn, William J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USAUniv Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
机构:
Univ Virginia, Dept Med, Charlottesville, VA USA
Univ Virginia, Ctr Immun Inflammat & Regenerat Med, Charlottesville, VA USAUniv Virginia, Dept Med, Charlottesville, VA USA
Li, Li
Huang, Liping
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Dept Med, Charlottesville, VA USA
Univ Virginia, Ctr Immun Inflammat & Regenerat Med, Charlottesville, VA USAUniv Virginia, Dept Med, Charlottesville, VA USA
Huang, Liping
Vergis, Amy L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Dept Med, Charlottesville, VA USA
Univ Virginia, Ctr Immun Inflammat & Regenerat Med, Charlottesville, VA USAUniv Virginia, Dept Med, Charlottesville, VA USA
Vergis, Amy L.
Ye, Hong
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Dept Med, Charlottesville, VA USA
Univ Virginia, Ctr Immun Inflammat & Regenerat Med, Charlottesville, VA USAUniv Virginia, Dept Med, Charlottesville, VA USA
Ye, Hong
Bajwa, Amandeep
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Dept Med, Charlottesville, VA USA
Univ Virginia, Ctr Immun Inflammat & Regenerat Med, Charlottesville, VA USAUniv Virginia, Dept Med, Charlottesville, VA USA
Bajwa, Amandeep
Narayan, Vivek
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Dept Med, Charlottesville, VA USA
Univ Virginia, Ctr Immun Inflammat & Regenerat Med, Charlottesville, VA USAUniv Virginia, Dept Med, Charlottesville, VA USA
Narayan, Vivek
Strieter, Robert M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Dept Med, Charlottesville, VA USA
Univ Virginia, Ctr Immun Inflammat & Regenerat Med, Charlottesville, VA USAUniv Virginia, Dept Med, Charlottesville, VA USA
Strieter, Robert M.
Rosin, Diane L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Ctr Immun Inflammat & Regenerat Med, Charlottesville, VA USA
Univ Virginia, Dept Pharmacol, Charlottesville, VA 22908 USAUniv Virginia, Dept Med, Charlottesville, VA USA
Rosin, Diane L.
Okusa, Mark D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Dept Med, Charlottesville, VA USA
Univ Virginia, Ctr Immun Inflammat & Regenerat Med, Charlottesville, VA USAUniv Virginia, Dept Med, Charlottesville, VA USA
机构:
Univ Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USAUniv Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
Fahmy, Marianne
Ramamoorthy, Sonia
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Inflammatory Bowel Dis, Dept Surg, La Jolla, CA USAUniv Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
Ramamoorthy, Sonia
Hata, Tissa
论文数: 0引用数: 0
h-index: 0
机构:
UC San Diego Hlth Syst, Div Dermatol, La Jolla, CA USAUniv Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
Hata, Tissa
Sandborn, William J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USAUniv Calif San Diego, Ctr Inflammatory Bowel Dis, Div Gastroenterol, La Jolla, CA 92093 USA
机构:
Univ Virginia, Dept Med, Charlottesville, VA USA
Univ Virginia, Ctr Immun Inflammat & Regenerat Med, Charlottesville, VA USAUniv Virginia, Dept Med, Charlottesville, VA USA
Li, Li
Huang, Liping
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Dept Med, Charlottesville, VA USA
Univ Virginia, Ctr Immun Inflammat & Regenerat Med, Charlottesville, VA USAUniv Virginia, Dept Med, Charlottesville, VA USA
Huang, Liping
Vergis, Amy L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Dept Med, Charlottesville, VA USA
Univ Virginia, Ctr Immun Inflammat & Regenerat Med, Charlottesville, VA USAUniv Virginia, Dept Med, Charlottesville, VA USA
Vergis, Amy L.
Ye, Hong
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Dept Med, Charlottesville, VA USA
Univ Virginia, Ctr Immun Inflammat & Regenerat Med, Charlottesville, VA USAUniv Virginia, Dept Med, Charlottesville, VA USA
Ye, Hong
Bajwa, Amandeep
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Dept Med, Charlottesville, VA USA
Univ Virginia, Ctr Immun Inflammat & Regenerat Med, Charlottesville, VA USAUniv Virginia, Dept Med, Charlottesville, VA USA
Bajwa, Amandeep
Narayan, Vivek
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Dept Med, Charlottesville, VA USA
Univ Virginia, Ctr Immun Inflammat & Regenerat Med, Charlottesville, VA USAUniv Virginia, Dept Med, Charlottesville, VA USA
Narayan, Vivek
Strieter, Robert M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Dept Med, Charlottesville, VA USA
Univ Virginia, Ctr Immun Inflammat & Regenerat Med, Charlottesville, VA USAUniv Virginia, Dept Med, Charlottesville, VA USA
Strieter, Robert M.
Rosin, Diane L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Ctr Immun Inflammat & Regenerat Med, Charlottesville, VA USA
Univ Virginia, Dept Pharmacol, Charlottesville, VA 22908 USAUniv Virginia, Dept Med, Charlottesville, VA USA
Rosin, Diane L.
Okusa, Mark D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Dept Med, Charlottesville, VA USA
Univ Virginia, Ctr Immun Inflammat & Regenerat Med, Charlottesville, VA USAUniv Virginia, Dept Med, Charlottesville, VA USA