Differential in situ expression of IL-17 in skin diseases

被引:28
作者
Fischer-Stabauer, Mattias [1 ]
Boehner, Alexander [2 ,3 ]
Eyerich, Stefanie [2 ,3 ]
Carbone, Teresa [4 ]
Traidl-Hoffmann, Claudia [1 ]
Schmidt-Weber, Carsten B. [2 ,3 ]
Cavani, Andrea [4 ]
Ring, Johannes [1 ]
Hein, Ruediger [1 ]
Eyerich, Kilian [1 ]
机构
[1] Tech Univ Munich, Dept Dermatol & Allergy, D-80290 Munich, Germany
[2] Tech Univ Munich, ZAUM, Ctr Allergy & Environm, D-80290 Munich, Germany
[3] Helmholtz Ctr Munich, Munich, Germany
[4] IDI IRCCS, Expt Immunol Lab, Rome, Italy
关键词
Interleukin (IL)-17; neutrophil granulocyte; Th17; T cell;
D O I
10.1684/ejd.2012.1854
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: Interleukin (IL)-17 is a key molecule for epithelial immunity and inflammation. Objectives: To quantify IL-17 expression in situ in a large panel of cutaneous diseases. Materials & Methods: 289 samples of the 30 most common cutaneous infectious, autoimmune, inflammatory and tumor diseases were stained for IL-17 immunohistochemically. Results: IL-17 expression strongly varied between the diseases, but was conserved within each disease. The major cellular sources of IL-17 were T cells and granulocytes. Skin diseases caused by extracellular microbials were infiltrated by many IL-17+ cells, while intracellular infections were scarcely positive for IL-17. While autoimmune diseases were mostly accompanied by IL-17+ T cells, IL-17+ granulocytes were dominant in neutrophilic dermatoses. Conclusion: Cutaneous diseases show a characteristic pattern of IL-17+ cellular infiltrate. These patterns are relevant for the clinician, since therapeutic approaches targeting differentiation of Th17 cells as well as direct targeting of IL-17 are or will become available.
引用
收藏
页码:781 / 784
页数:4
相关论文
共 11 条
  • [1] Patients with Chronic Mucocutaneous Candidiasis Exhibit Reduced Production of Th17-Associated Cytokines IL-17 and IL-22
    Eyerich, Kilian
    Foerster, Stefanie
    Rombold, Stephanie
    Seidl, Hans-Peter
    Behrendt, Heidrun
    Hofmann, Heidelore
    Ring, Johannes
    Traidl-Hoffmann, Claudia
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2008, 128 (11) : 2640 - 2645
  • [2] IL-17 in atopic eczema: Linking allergen-specific adaptive and microbial-triggered innate immune response
    Eyerich, Kilian
    Pennino, Davide
    Scarponi, Claudia
    Foerster, Stefanie
    Nasorri, Francesca
    Behrendt, Heidrun
    Ring, Johannes
    Traidl-Hoffmann, Claudia
    Albanesi, Cristina
    Cavani, Andrea
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 123 (01) : 59 - 66
  • [3] Eyerich S, N ENGL J MED, V365, P231
  • [4] IL-17 and IL-22: siblings, not twins
    Eyerich, Stefanie
    Eyerich, Kilian
    Cavani, Andrea
    Schmidt-Weber, Carsten
    [J]. TRENDS IN IMMUNOLOGY, 2010, 31 (09) : 354 - 361
  • [5] Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling
    Eyerich, Stefanie
    Eyerich, Kilian
    Pennino, Davide
    Carbone, Teresa
    Nasorri, Francesca
    Pallotta, Sabatino
    Cianfarani, Francesca
    Odorisio, Teresa
    Traidl-Hoffmann, Claudia
    Behrendt, Heidrun
    Durham, Stephen R.
    Schmidt-Weber, Carsten B.
    Cavani, Andrea
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (12) : 3573 - 3585
  • [6] Ustekinumab for Peristomal Pyoderma Gangrenosum
    Fahmy, Marianne
    Ramamoorthy, Sonia
    Hata, Tissa
    Sandborn, William J.
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2012, 107 (05) : 794 - 795
  • [7] Interleukin 23 Expression in Pyoderma Gangrenosum and Targeted Therapy With Ustekinumab
    Guenova, Emmanuella
    Teske, Anna
    Fehrenbacher, Birgit
    Hoerber, Sebastian
    Adamczyk, Annette
    Schaller, Martin
    Hoetzenecker, Wolfram
    Biedermann, Tilo
    [J]. ARCHIVES OF DERMATOLOGY, 2011, 147 (10) : 1203 - 1205
  • [8] IL-17 and Th17 Cells
    Korn, Thomas
    Bettelli, Estelle
    Oukka, Mohamed
    Kuchroo, Vijay K.
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 2009, 27 : 485 - 517
  • [9] IL-17 produced by neutrophils regulates IFN-γ-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury
    Li, Li
    Huang, Liping
    Vergis, Amy L.
    Ye, Hong
    Bajwa, Amandeep
    Narayan, Vivek
    Strieter, Robert M.
    Rosin, Diane L.
    Okusa, Mark D.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (01) : 331 - 342
  • [10] IL-17 Amplifies Human Contact Hypersensitivity by Licensing Hapten Nonspecific Th1 Cells to Kill Autologous Keratinocytes
    Pennino, Davide
    Eyerich, Kilian
    Scarponi, Claudia
    Carbone, Teresa
    Eyerich, Stefanie
    Nasorri, Francesca
    Garcovich, Simone
    Traidl-Hoffmann, Claudia
    Albanesi, Cristina
    Cavani, Andrea
    [J]. JOURNAL OF IMMUNOLOGY, 2010, 184 (09) : 4880 - 4888