Certain types of iron oxide nanoparticles are not suited to passively target inflammatory cells that infiltrate the brain in response to stroke

被引：25

作者：

Harms, Christoph ^{[1
,2
]}

Datwyler, Anna Lena ^{[1
]}

Wiekhorst, Frank ^{[3
]}

Trahms, Lutz ^{[3
]}

Lindquist, Randall ^{[4
]}

Schellenberger, Eyk ^{[4
]}

Mueller, Susanne ^{[1
]}

Schuetz, Gunnar ^{[5
]}

Roohi, Farnoosh ^{[5
]}

Ide, Andreas ^{[5
]}

Fuechtemeier, Martina ^{[1
]}

Gertz, Karen ^{[1
]}

Kronenberg, Golo ^{[1
]}

Harms, Ulrike ^{[1
,2
]}

Endres, Matthias ^{[1
,2
,6
]}

Dirnagl, Ulrich ^{[1
,6
]}

Farr, Tracy D. ^{[1
]}

机构：

[1] Charite, Ctr Stroke Res Berlin CSB, Dept Expt Neurol, D-10117 Berlin, Germany

[2] Charite, Klin & Hsch Ambulanz Neurol, D-13353 Berlin, Germany

[3] Phys Tech Bundesanstalt, Berlin, Germany

[4] Charite, Dept Radiol, D-10117 Berlin, Germany

[5] Bayer HealthCare Pharmaceut, MR & CT Contrast Media Res, Berlin, Germany

[6] Charite, Excellence Cluster NeuroCure, D-10117 Berlin, Germany

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2013年 / 33卷 / 05期

关键词：

inflammation; iron oxide nanoparticles; magnetic resonance imaging; stroke; CEREBRAL-ARTERY OCCLUSION; FOCAL ISCHEMIA; MACROPHAGES; MICE; MRI;

D O I：

10.1038/jcbfm.2013.22

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The present study aimed to determine the most suitable timepoint for administration of three different types of iron oxide nanoparticles in order to image leukocyte migration into the ischemic brain. Half lives of all particles were short, blood leukocyte uptake poor, and iron accumulation was only observed in the organs. The selected particles, despite being similar to previous reports, are not ideal for leukocyte tracking.

引用

页码：795 / 796

页数：2

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