Preparation and characterization of chitosan/sodium cellulose sulfate/silver nanoparticles composite films for wound dressing

被引：16
作者：
Tang, Chuan [1 ]
Zhao, Bing [1 ]
Zhu, Jiajun [1 ]
Lu, Xuan [1 ]
Jiang, Ge [1 ]
机构：
[1] Dalian Univ, Coll Life Sci & Technol, Dalian 116622, Peoples R China
来源：
MATERIALS TODAY COMMUNICATIONS | 2022年 / 33卷
基金：
中国国家自然科学基金;
关键词：
Chitosan; Sodium cellulose sulfate; Wound dressing; Antibacterial activity; Cytocompatibility; Wound healing; SILVER NANOPARTICLES; ANTIBACTERIAL; SPONGE; FABRICATION; COMPLEX;
D O I：
10.1016/j.mtcomm.2022.104192
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Chitosan/sodium cellulose sulfate (CS/NaCS) composite film incorporated with silver nanoparticles (AgNPs) for wound dressing was prepared. Morphology, mechanical properties, porosity, water vapor transmission rate, and water absorption properties of CS/NaCS composite films were investigated. It was demonstrated that the composite film with the CS, NaCS mass ratio of 2:1 had a porous structure with a porosity of 82.40 +/- 1.05 %. The swelling rate and water vapor transmission rate of CN21 composite films were 1670.7 +/- 37.5 % and 1053.8 +/- 19.1 g.m(-2).d(-1), respectively. The CS/NaCS/AgNPs composite film showed excellent antibacterial properties against E. coli and S. aureus. The hemolysis rate of CS/NaCS/AgNPs composite film is less than 5 %, which could be considered to meet the requirements of biomedical materials. In addition, the CS/NaCS/AgNPs composite film exhibited favorable cytocompatibility and the wound closure rate treated by CS/NaCS/AgNPs film reached to 96.17 +/- 1.05 % after 12 days. In other words, the CS/NaCS/AgNPs composite film could promote wound tissue contraction and internal tissue growth, showing a good wound healing effect. Thus the CS/NaCS/AgNPs composite film has potential application in wound dressing.
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页数：9
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